KHẢO SÁT NỒNG ĐỘ HEPCIDIN HUYẾT TƯƠNG Ở BỆNH NHÂN BỆNH THẬN MẠN TÍNH GIAI ĐOẠN CUỐI LỌC MÁU CHU KỲ

Abstract

Objectives: To evaluate plasma hepcidin concentrations and its relation with some clinical and subclinical indicators in patients on maintenance hemodialysis (HD). Subjects and methods: A cross-sectional, descriptive study on 117 maintenance hemodialysis patients and 57 healthy controls matched for age and gender at 103 Military Hospital from January, 2022 to December, 2023. All above patients had measured plasma Hepcidin by ELISA method. Results: The concentration of plasma hepcidin in the group of patients on hemodialysis 3,63 (2,24 – 21,4 ng/mL) was higher than in the control group 2,80 (1,27 – 3,90 ng/ml), p< 0,005. 40,2% of patients increased the concentration of hepcidin compared to the control group. The hepcidin concentration was positively and significantly correlated with age (r=0,241), dialysis time (r=0,18), plasma ferritin (r = 0,19) and CRP (r = 0,417), p< 0,05. Meanwhile, there is a statistically significant negative correlation with hemoglobin (r = -0,303), plasma albumin (r = -0,375), p< 0,05. Conclusion: Plasma hepcidin concentration is elevated in patients with end-stage chronic kidney disease on hemodialysis. Plasma hepcidin concentration is positively related to age, dialysis time, plasma ferritin, CRP and negatively related to hemoglobin, albumin concentration.