ĐÁNH GIÁ TƯƠNG QUAN GIỮA MỘT SỐ THÔNG SỐ GIẢM OXY MÁU VỀ ĐÊM VỚI HBA1C Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÍP 2

Abstract

Objective: This study aims to Evaluate the correlation between nocturnal hypoxemia parameters and HbA1c levels in patients with type 2 diabetes mellitus. Subjects and methods: A cross-sectional descriptive study was conducted on 96 type 2 diabetes patients at the Can Tho University of Medicine and Pharmacy Hospital from March 2023 to March 2024. Results: Regarding general characteristics, the majority of participants were female (64.6%), with an average age of 67.31 ± 12.9, and 43.8% were diagnosed with Obstructive Sleep Apnea (OSA). Clinically, most patients exhibited symptoms such as apnea/hypopnea, snoring, morning headaches, and waking up feeling tired (>85%). Polysomnographic features showed that the OSA group had significantly higher Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) values than the non-OSA group (17.41 ± 13.28 vs. 7.1 ± 13.4 and 21.35 ± 14.95 vs. 8.31 ± 14.28, respectively, all p < 0.001). Additionally, the mean SpO2 was lower in patients with OSA compared to those without (p = 0.04). Correlation analysis revealed a positive correlation between HbA1c levels and both AHI and ODI; however, these correlations were very weak and not statistically significant (all 0 < r < 0.2; p > 0.05). Conclusion: In patients with type 2 diabetes mellitus, classic symptoms of OSA are prominently displayed. Polysomnographic indices AHI, ODI, and mean SpO2 indicate more severe nocturnal hypoxemia in the OSA group compared to the non-OSA group. HbA1c levels showed a positive but very weak correlation with AHI and ODI indices, with no significant difference.