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SURVEY OF CHARACTERISTICS OF CEREBRAL VASCULAR OBSTRUCTION IN MRI 3 TESTA AND CYP2C19 GENETIC POLYMORPHISMS IN ISCHEMIC STROKE PATIENTS
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Abstract
Objective: Examine the characteristics of cerebrovascular damage and assess the CYP2C19*2 and CYP2C19*3 gene polymorphisms in ischemic stroke patients at Can Tho Stroke International Services. Materials and methods: Conduct a cross-sectional descriptive study involving 83 ischemic stroke patients diagnosed using 3 Tesla MRI or subtraction cerebral angiography at Can Tho Stroke International Services. Results: The study group had a male-to-female ratio of 2:1, with an average age of 63.96 ± 11.91. Severe target vessel stenosis predominated in 54.1% of cases based on 3T MRI and DSA. Arterial stenosis lengths less than 5mm were observed in 36 cases (59%). M1 middle cerebral artery stenosis had the highest incidence, constituting 38% and 33.3% of cases in the 3T MRI and DSA diagnostic methods, respectively. In terms of Clopidogrel metabolism and CYP2C19 2, 3 gene polymorphisms, only 42.2% of patients exhibit normal metabolism, while 12% have poor metabolism, and 45.8% show intermediate metabolism. Notably, 56.6% of patients carry the CYP2C19*2 polymorphism, with the CYP2C19*1*2 heterozygous form accounting for a significant portion (47%) and the CYP2C19*2*2 homozygous form comprising 9.6%. Additionally, 3.6% of patients carry the CYP2C19*3 polymorphism, all of whom are CYP2C19*1*3 heterozygous. Conclusion: A high proportion (57.8%) of patients carry CYP2C19*2 and CYP2C19*3 genes, which result in reduced or lost Clopidogrel activity. The heterozygous *2 allele is the most commonly observed
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Keywords
Ischemic stroke, MRI 3testla, DSA, Clopidogrel, CYP2C19.
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