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STUDY ON THE EFFECTS OF THE CAPSULE “TD.NQ” IN THE TREATMENT OF KNEE OSTEOARTHRITIS IN EXPERIMENT
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Abstract
Objective: Study the treatment effects of knee osteoarthritis of capsules "TD.NQ" on experimental animals. Subjects and methods: Wistar white rats (provided by the Vietnam Military Medical Academy). Both breeds, healthy, weight 180 ± 40 g. Method: Research on the treatment of knee osteoarthritis with TD.NQ capsules on mice with MIA-induced knee osteoarthritis, through inflammatory cytokine indices, knee joint area diameter and histopathology. Results: At a dose of 12,798 g/kg, the increase in knee joint diameter in mice decreased compared to the model group at all times, especially at the time of after 1, 3, 4 and 5 weeks (p < 0.05, p < 0.01). This effect is better than the dose of 4,266 g/kg but didn’t pass Diclofenac 3mg/kg. At a dose of 12,798 g/kg, interleukin-1β concentration decreased significantly compared to the model batch (p < 0.01), with no difference compared to the biological control and compared to diclofenac 3mg/kg (p > 0.05). At a dose of 12,798 g/kg, TNF-α concentration decreased significantly compared to the model batch (p < 0.05), not different from the biological control and diclofenac 3mg/kg (p > 0 .05). The knee joint histopathological damage score decreased from 50 to 36 and 35 in the two treatment batches respectively. Conclusion: TD.NQ both doses 4,266 g/kg and 12,798 g/kg are effective in reducing interleukin-1β and TNF-α indices, reducing the diameter of the knee joint area on inflamed knee joints, and improving joint histopathology. research mouse pillow. TD.NQ dose 12,798 g/kg tends to have a better effect than dose 4,266 g/kg, but the difference is not statistically significant.
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Keywords
osteoarthritis, TD.NQ, traditional medicine.
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