TÌNH HÌNH KHÁNG KHÁNG SINH CỦA VI KHUẨN LẬU TẠI BỆNH VIỆN DA LIỄU TRUNG ƯƠNG NĂM 2022

Abstract

Background: Gonorrhea, caused by Neisseria gonorrhoeae, presents a growing public health concern due to the escalating antimicrobial resistance. Methods: To assess the extent of drug resistance in Neisseria gonorrhoeae, we conducted a cross-sectional study involving patients with positive cultures for the bacterium at the National Hospital of Dermatology and Venereology in 2022. Results: 85.0% of the cases were male, and 51.7% of infections belonged to the under-30 age group (n=60). Resistance to ciprofloxacin and decreased susceptibility to penicillin were observed in all isolates, while the rate of decreased tetracycline susceptibility was 98.3%. Additionally, 5.0% of isolates demonstrated non-susceptibility to azithromycin, and 1.7% were non-susceptible to cefixime, ceftriaxone, and cefotaxime. Notably, no isolate displayed resistance to spectinomycin. Conclusion: Cefixime, ceftriaxone, cefotaxime, and spectinomycin retained their high efficacy as treatments for gonorrhea. However, the use of azithromycin for gonococcal therapy warrants careful consideration. These findings emphasize the importance of continuous surveillance of antimicrobial resistance patterns in Neisseria gonorrhoeae.