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Date Published: 05/05/2024
Abstract Views: 97
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DOI: https://doi.org/10.51298/vmj.v538i1.9378
Issue
Vol. 538 No. 1 (2024)
Section
Các bài báo
How to Cite
Phan, Đình P., Lê, C. K., & Phạm, N. H. (2024). PROGNOSTIC VALUE ABOUT ARRHYTHMIC EVENTS OF PROGRAMMED ELECTRICAL STIMULATION IN ASYMPTOMATIC PATIENTS WITH BRUGADA SYNDROME. Vietnam Medical Journal, 538(1). https://doi.org/10.51298/vmj.v538i1.9378

PROGNOSTIC VALUE ABOUT ARRHYTHMIC EVENTS OF PROGRAMMED ELECTRICAL STIMULATION IN ASYMPTOMATIC PATIENTS WITH BRUGADA SYNDROME

Đình Phong Phan, Cao Khánh Lê, Như Hùng Phạm

Main Article Content

Abstract

Aim: The aim was to evaluate the ability of programmed electrical stimulation (PES) to predict future ventricular arrhythmia events in asymptomatic Brugada patients. Result: During the period from May 2018 to June 2023, 63 patients (60 males; 3 females; age mean, 48 ± 13) diagnosed with asymptomatic Brugada Syndrome (based on a documented spontaneous type 1 ECG) underwent programmed electrical stimulation at the Vietnam National Heart Institute and Hanoi Heart Hospital. Malignant ventricular arrhythmias (ventricular fibrillation and/or polymorphic ventricular tachycardia) were induced in 15 patients (24%), 11 patients in this group were implanted implantable cardioverter defibrillator (ICD), 4 were not. After a mean follow-up of 30 ± 19 months, 4 arrhythmic events occurred (3 patients experienced appropriate ICD shocks, and 1 died). All patients with fatal arrhythmic events were in the inducible group. Conclusion: Programmed electrical stimulation is a strong predictor of fatal arrhythmic events in asymptomatic patients with Brugada syndrome.

Article Details

Keywords

Brugada Syndrome, Programmed Electrical Stimulation, Arrhythmic events

References

1. Sieira J, Brugada P. The definition of the Brugada syndrome. Eur Heart J. 2017;38(40): 3029-3034.
2. Malik BR, Ali Rudwan AM, Abdelghani MS, et al. Brugada Syndrome: Clinical Features, Risk Stratification, and Management. Heart Views. 2020;21(2):88-96.
3. Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC). European Heart Journal. 2022;43(40): 3997-4126.
4. Brugada P, Brugada R, Mont L, Rivero M, Geelen P, Brugada J. Natural history of Brugada syndrome: the prognostic value of programmed electrical stimulation of the heart. J Cardiovasc Electrophysiol. 2003;14(5):455-457.
5. Probst V, Veltmann C, Eckardt L, et al. Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation. 2010; 121(5):635-643.
6. Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC. Brugada Syndrome. JACC Clin Electrophysiol. 2022;8(3):386-405.
7. Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005;111(5):659-670.