NGHIÊN CỨU MỐI TƯƠNG QUAN GIỮA HOMA-IR VÀ MỘT SỐ CHỈ SỐ LIPID HUYẾT TƯƠNG TRÊN BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÝP 2

Abstract

Introduction: Diabetes and lipid metabolism disorder (LMD) are two common metamolic dysregulations with increased and rejuvenation trend globally. Insuline resistance affects treatment efficacy of diabetes. The association between diabetes and LMD was reported. However, the relationship between insuline resistance and LMD is not clearly reported yet. Materials and methods: Cross-sectional analysis study comparing control group, including 3 groups: group 1: type 2 diabetes with LMD, (n=100); group 2: type 2 diabetes without LDM (NLMD, n=100); and group 3: healthy control (HC, n=100). Statistical analysis was performed on STATA 14.0 and GraphPad Prism 8.0. Results: HOMA-IR was significantly higher among type 2 diabetes patients, and increased HOMA-IR occurred among 90% of type 2 diabetes. There was a positive correlation between HOMA-IR and the concentration of cholesterol, tryglycerid and LDL-C, and negative correlation between HOMA-IR and HDL-C in serum. Conclusion: Type 2 diabetes patients showed high HOMA-IR index compared to HC. The HOMA-IR index positively correlated with plasma cholesterol, tryglyceride and LDL-cholesterol concentrations and negatively correlated with plasma HDL-cholesterol concentration.