SURVIVAL IN NEUROENDOCRINE CERVICAL CANCER TREATED WITH CONCURRENT CHEMORADIOTHERAPY USING EP REGIMEN IN K HOSPITAL

Chí Việt Nguyễn , Anh Dũng Tô, Công Hoàng Nguyễn , Thị Vân Anh Đặng

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Abstract

Objective: To analyze patterns of the overall survival and disease-free survival in women with neuroendocrine cervical cancer (NECC) undergoing concurrent chemoradiotherapy using EP regimen at K Hospital between 2018 and 2023. Methods: A retrospective study of patients with FIGO stage I-IVA NECC who were treated with concurrent chemoradiotherapy using EP regimen. Disease-free survival (DFS) and overall survival (OS) according to disease and clinical characteristics were analyzed using Kaplan-Meiee method. Results: Among 72 patients with NECC, with a medial follow-up of 25 months (ranging from 6.5 to 64.3 months), 5 patients (6.9%) experienced local recurrence, 34 patients (47,2%) had distant metastatic and 35 (48,6%) died. The medial overall survival was 31.9 months. OS-2years and OS-5years were observed at 61.7% and 45.5%, respectively. The medial DFS was 25.4 months, with DFS-2years and 5years were 54.9% and 44.2%, respectively. Conclusion: Neuroendocrine cervical cancer was an agrgressive disease with poor prognosis. Noteworthy occurrences of mortality and disease progression manifest within the initial two years following treatment initiation.

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References

1. Diệu, B., Ung thư cổ tử cung. Hướng dẫn chẩn đoán và điều trị một số bệnh ung thư thường gặp, 2016. Nhà xuất bản Y học: p. 308-318.
2. Hsu, H.C., et al., Surveillance epidemiology and end results analysis demonstrates improvement in overall survival for cervical cancer patients treated in the era of concurrent chemoradiotherapy. Front Oncol, 2015. 5: p. 81.
3. Lee, S.W., et al., Unfavorable prognosis of small cell neuroendocrine carcinoma of the uterine cervix: a retrospective matched case-control study. Int J Gynecol Cancer, 2010. 20(3): p. 411-6.
4. Tempfer, C.B., et al., Neuroendocrine carcinoma of the cervix: a systematic review of the literature. BMC cancer, 2018. 18(1): p. 530-530.
5. Intaraphet, S., et al., Prognostic factors for small cell neuroendocrine carcinoma of the uterine cervix: an institutional experience. Int J Gynecol Cancer, 2014. 24(2): p. 272-9.
6. Al-Hiyasat, A.S., K.M. Barrieshi-Nusair, and M.A. Al-Omari, The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study. J Am Dent Assoc, 2006. 137(12): p. 1699-705.
7. Cohen, J.G., et al., Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. Am J Obstet Gynecol, 2010. 203(4): p. 347.e1-6.
8. Zivanovic, O., et al., Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy. Gynecol Oncol, 2009. 112(3): p. 590-3.
9. Sodsanrat, K., N. Saeaib, and T. Liabsuetrakul, Comparison of Clinical Manifestations and Survival Outcomes between Neuroendocrine Tumor and Squamous Cell Carcinoma of the Uterine Cervix: Results from a Tertiary Center in Southern Thailand. J Med Assoc Thai, 2015. 98(8): p. 725-33.
10. Stecklein, S.R., et al., Patterns of recurrence and survival in neuroendocrine cervical cancer. Gynecol Oncol, 2016. 143(3): p. 552-557.