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Date Published: 10/05/2024
Abstract Views: 69
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DOI: https://doi.org/10.51298/vmj.v538i2.9486
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Vol. 538 No. 2 (2024)
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Trần, N. Q., & Nguyễn , T. T. D. (2024). APPLICATION OF NUCLEIC ACID TEST TO DETERMINE THE PREVALENCE OF OCCULT HEPATITIS B INFECTION IN BLOOD DONORS IN NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION, PERIOD 2021-2023. Vietnam Medical Journal, 538(2). https://doi.org/10.51298/vmj.v538i2.9486

APPLICATION OF NUCLEIC ACID TEST TO DETERMINE THE PREVALENCE OF OCCULT HEPATITIS B INFECTION IN BLOOD DONORS IN NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION, PERIOD 2021-2023

Ngọc Quế Trần, Thị Thanh Dung Nguyễn

Main Article Content

Abstract

Occult HBV Infection (OBI) remains a potential threat to blood transfusion safety, especially in developing countries. Nevertheless, there is no data available on the magnitude of occult HBV infection among blood donors at the National Institute of Hematology and Blood Transfusion (NIHBT). Objectives: (1) Determine the rate of OBI in blood donors at the NIHBT and (2) Conduct a survey on the titre of anti-HBs in OBI blood donors. Subjects: The research subjects for first goal were 625,548 blood donors with HBsAg(-) from 01/01/2021 to 30/06/2023 and the research subjects of second goal were 187 OBI donors. Method: Cross-sectional descriptive study. Results: The rate of OBI blood donors at the NIHBT in the period 2021-2023 is 0.06%. Among OBI blood donors: the average age was 40 (IQR: 33 - 49), male accounted for 61.0% and female accounted for 39.0%; First-time blood donors accounted for 44.0% and repeat blood donors accounted for 56.0%. There were 59.9% of OBI blood donors negative for anti-HBs, 26.7% of blood donors had anti-HBs antibody titers in the range of 10-100 IU/mL, with a median concentration of 33.6 (IQR: 16.2 - 56.6) IU/mL, only 13.4% of blood donors had anti-HBs concentrations above 100 IU/mL with a median concentration of 282.0 (IQR: 131 - 526.5) IU/mL.

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