NGHIÊN CỨU PILOT VỀ BIẾN THỂ ĐA HÌNH rs216321 VÀ MỘT SỐ ĐẶC ĐIỂM CỦA Ổ XUẤT HUYẾT Ở NGƯỜI XUẤT HUYẾT NỘI SỌ TỰ PHÁT

Abstract

Background: Polymorphic variant rs216321 on the VWF gene helps predict hematoma expansion in cases of spontaneous intracranial hemorrhage (sICH). There is currently no data on this variant in Vietnam. Objective: initially determine the prevalence of this rs216321 variant in a population with ICH and characterize the presence of the variant according to some characteristics of the foci of haemorrhage. Subjects and methods: a case series study, convenient and prospective sampling, on 96 patients diagnosed with sICH, at Nguyen Tri Phuong hospital, from 10/2022 to 06/2023. The rs216321 variant was identified using the SYBR real-time PCR technique. Collect data on age, gender, location, number of hemorrhagic foci, diameter of hemorrhagic foci. Data was analyzed using STATA 14.2 software. Using the Chi squared and MannWhitney tests with a significant difference of p<0.05. Results: the proportion of risk alleles (T allele) accounted for 28%, the proportion of CC, CT and TT genotypes was 50.0%, 43.8% and 6.2%, respectively. When comparisons were made between the group without variants (genotype CC)(n=48) and the group with variants (genotypes CT and TT)(n=48), there was no difference in characteristics of age, gender, location of haemorrhage, number of foci of haemorrhage, and hematoma volume. Conclusions: The study provides preliminary data for evaluating the role of this variant in the potential spread of hematomas.