Article Sidebar

PDF
Date Published: 11/05/2024
Abstract Views: 70
Views PDF: 94
DOI: https://doi.org/10.51298/vmj.v538i1.9523
Issue
Vol. 538 No. 1 (2024): Vietnam Medical Journal
Section
Các bài báo
How to Cite
Mai, T. C. ., Nguyen, T. P. ., Nguyen, T. N. ., Nguyen, T. V. ., & Luong, T. L. . (2024). ACUTE RHABDOMYOLYSIS IN A JUVENILE WITH DENGUE FEVER: A RARE MANIFESTATION BUT BEWARE. Vietnam Medical Journal, 538(1). https://doi.org/10.51298/vmj.v538i1.9523

ACUTE RHABDOMYOLYSIS IN A JUVENILE WITH DENGUE FEVER: A RARE MANIFESTATION BUT BEWARE

Thanh Cong Mai1,, Trong Phuoc Nguyen1, Thanh Nam Nguyen2, Thi Van Nguyen3, Thi Lien Luong4
1 Hanoi Medical University
2 Bach Mai Hospital
3 National Children’s Hospital
4 Hanoi Medical University Hospital

Main Article Content

Abstract

Myalgia is a common symptom in patients with Dengue fever. However, acute rhabdomyolysis is a rare manifestation. The precise mechanism of Dengue-associated rhabdomyolysis has not been determined, it is thought likely to be caused by myotoxic cytokines released in response to viral infection, such as TNF and IFN-α. Here we report a case of a 13-year-old boy with Dengue fever, presenting with red urine on day 5 of illness. Together with a decreased platelet count (26 G/L), we initially suspected hematuria but the urinalysis showed no red blood cells. We then thought of rhabdomyolysis causing myoglobinuria, so we ordered diagnostic tests with the following results: CK 1353 U/L, GOT 361 U/L, GPT 90 U/L. The patient was given intravenous fluids and oral oresol to control urine output. Urine color faded and blood CK concentration returned to normal after 13 days. Rhabdomyolysis is rare in dengue fever but requires proper diagnosis and management to prevent acute kidney injury - a life-threatening complication.

Article Details

Keywords

Rhabdomyolysis, red urine, Dengue fever

References

1. World Health Organization (WHO). Dengue: guidelines for diagnosis, treatment, prevention and control. WHO, Geneva, 2009.
2. Gibbons RV, Vaughn DW. Dengue: an escalating problem. BMJ. 2002;324(7353):1563-6.
3. Solomon T, Dung NM, Vaughn DW, et al. Neurological manifestations of dengue infection. Lancet. 2000;355(9209):1053-9.
4. Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. N Engl J Med. 2009;361(1):62-72.
5. Davis JS, Bourke P. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis. 2004;38(10):e109-11.
6. Salgado DM, Eltit JM, Mansfield K, et al. Heart and skeletal muscle are targets of dengue virus infection. Pediatr Infect Dis J. 2010;29(3):238-42
7. Lim M, Goh HK. Rhabdomyolysis following dengue virus infection. Singapore Med J. 2005;46(11):645-6.
8. Cabral BMI, Edding SN, Portocarrero JP, et al. Rhabdomyolysis. Dis Mon. 2020;66(8):101015.
9. Dall'Aglio A, Kissling S, Vollenweider P, et al. [Rhabdomyolysis: early management]. Rev Med Suisse. 2020;16(716):2272-8.
10. Lee IK, Liu JW, Yang KD. Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure. Am J Trop Med Hyg. 2009;80(4):651-5.
11. Sargeant T, Harris T, Wilks R, et al. Rhabdomyolysis and dengue Fever: a case report and literature review. Case Rep Med. 2013;2013:101058.
12. Nakamura M, Ikeda S, Nagahara H, et al. A Patient with Dengue Fever Presenting with Rhabdomyolysis. Intern Med. 2015;54(13):1657-60.