MỐI LIÊN QUAN GIỮA THỤ THỂ ESTROGEN VỚI ĐẶC ĐIỂM LÂM SÀNG Ở BỆNH NHÂN LUPUS BAN ĐỎ HỆ THỐNG

Abstract

Objective: To investigate the relationship between the presence of estrogen receptor α (ERα) in the skin lesions and clinical characteristics of patients with systemic lupus erythematosus (SLE).Subjects and methods: This is a case seriers of 65 female patients diagnosed with systemic lupus erythematosus at the National Dermatology Hospital from January 2022 to August 2023. Clinical charactereristics were examined in all 65 patients. Histopathological examination and immunohistochemical staining was conducted among 36 of 65 patients to detect the presence of ERα in the skin lesions. Results: The average age of SLE patients was 30.72±15.1. Acute skin lesions are the most common, accounting for 60%, followed by subacute skin lesions (27.7%) and chronic skin lesions (12.3%). Among specific skin lesions, butterfly rash is the most common (36.9%), while photosensitivity is the most common non-specific skin lesions (52.3%). ERα was positive in 38.9% of cases and negative in 61.1% of cases. There is no relationship between ERα receptor and age group, classification of lupus erythematosus, specific skin lesions and non-specific skin lesions. Conclusion: In our study, skin lesions are very common and diverse in patients with systemic lupus erythematosus. The presence of ERα in skin lesions was detected in 38.9% of SLE cases. No association was found between the presence of ERα in skin lesions and clinical characteristics of SLE patients.