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CHARACTERISTICS OF HLA- ANTIGENS AND COMPATIBILITY IN LIVING RELATED -KIDNEY TRANSPLANTATION AT VIET DUC HOSPITAL
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Abstract
Objective: To investigate the characteristics of HLA antigens and HLA compatibility in blood-related kidney transplant pairs at Viet Duc Hospital. Pateints and Research Methods: Clinical description and cross-sectional study on 84 pairs of kidney transplant donors and recipients from the same blood lineage. Study period: from January 2018 to December 2022. Research parameters include the age of donors and recipients, blood relationship (parent-child, sibling, etc.), HLA characteristics for each allele (A, B, DR B), subgrouping under each allele, and compatibility levels (3/6, 4/6, 5/6, 6/6). The frequency of each allele appearing in donors and recipients is also evaluated. Results: The minimum age of kidney donors is 30 years, with a maximum of 64 years, and a mean ± SD of 49.51 ± 7.30. Kidney recipients range from 18 to 58 years old, with a mean ± SD of 29.42 ± 6.57. Recipients between the ages of 21-40 constitute the majority at 94.05%. HLA compatibility between donor-recipient pairs from the same blood lineage is relatively high, primarily at 3/6 - 4/6 levels, accounting for 84.52%. The lowest compatibility is 2/6, observed in 2 cases (2.38%) among siblings. Seven cases show complete HLA compatibility at 6/6, mostly among siblings (57.14%). The most common alleles are HLA-A02 and HLA-A11, accounting for 23.8% and 35.4%, respectively. High-frequency alleles include A02, A11, A24, A29, A33, B15, DRB1*12, among others. Conclusion: HLA compatibility in related kidney transplantation is relatively high, predominantly at 3/6 - 4/6 levels, with a rate of 84.52%. The most common alleles include A11, HLA-B15, and HLA-DRB1*12
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Keywords
HLA, living related- kidney transplantation
References
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