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TO SURVEY THE POLYMORPHISMS OF MMP-3 AND MMP-9 GENES IN NORMAL PREGNANT WOMEN AT HA NOI OBSTETRICS AND GYNECOLOGY HOSPITAL
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Abstract
Objectives: To survey the polymorphisms of MMP-3 and MMP-9 genes in normal pregnant women at Hanoi Obstetrics and Gynecology Hospital. Subjects and methods: This study was conducted on 120 pregnant women with genotype MMP-3 (-1171 5A/6A) and MMP-9 (-1562 C>T) polymorphisms by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) technique. Results: A preeminent prevalence of the 6A allele in the MMP-3 polymorphism at 90,8% signifying the participants' predominance of the 6A/6A genotype. None of the women exhibited the 5A/5A genotype. For MMP-9 polymorphism, the majority was characterized by the C allele, with the CC homozygous genotype being most prevalent at 85,8%. The allele frequency distributions for MMP-3 and MMP-9 polymorphisms adhered to the principles of Hardy-Weinberg equilibrium. 60% pregnant women had genotype 6A/6A of MMP-3 polymorphism combined with CC genotype of MMP-9 polymorphism. Conclusions: The proportion of pregnant women carrying homozygous 6A/6A genotype for MMP-3 polymorphism and CC genotype for MMP-9 polymorphism accounted for the majority (81,7% and 73,35%, respectively
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Keywords
Pregnant women, Matrix metalloproteinase (MMP), MMP-3 polymorphism, MMP-9 polymorphism
References
2. Sakowicz A, Lisowska M, Biesiada L, et al. Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease Markers. 2018;2018.
3. Behforouz A, Dastgheib SA, Abbasi H, et al. Association of MMP-2, MMP-3, and MMP-9 Polymorphisms with Susceptibility to Recurrent Pregnancy Loss. Fetal Pediatr Pathol. 2021; 40(5):378-386.
4. Gremlich S, Nguyen D, Reymondin D, Hohlfeld P, Vial Y, Witkin SS, Gerber S. Fetal
MMP2/MMP9 polymorphisms and intrauterine growth restriction risk. J Reprod Immunol. 2007 Jun;74(1-2):143-51.
5. Maeda PM, Bicudo APSL, Watanabe RTM, et al. Study of the polymorphism rs3025058 of the MMP-3 gene and risk of pelvic organ prolapse in Brazilian women. European Journal of Obstetrics & Gynecology and Reproductive Biology: X. 2019;3:100031.
6. Palei ACT, Sandrim VC, Duarte G, Cavalli RC, Gerlach RF, Tanus-Santos JE. Matrix metalloproteinase (MMP)-9 genotypes and haplotypes in preeclampsia and gestational hypertension. Clin Chim Acta. 2010;411(11-12): 874-877.
7. Rahimi Z, Rahimi Z, Shahsavandi MO, Bidoki K, Rezaei M. MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia. Biomark Med. 2013;7(1):93-98.
8. Sun C, Zhang Q, Hu B, Zhang K. Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women. Genet Mol Res. 2016;15(3).