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TO SURVEY THE POLYMORPHISMS OF MMP-3 AND MMP-9 GENES IN NORMAL PREGNANT WOMEN AT HA NOI OBSTETRICS AND GYNECOLOGY HOSPITAL
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Abstract
Objectives: To survey the polymorphisms of MMP-3 and MMP-9 genes in normal pregnant women at Hanoi Obstetrics and Gynecology Hospital. Subjects and methods: This study was conducted on 120 pregnant women with genotype MMP-3 (-1171 5A/6A) and MMP-9 (-1562 C>T) polymorphisms by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) technique. Results: A preeminent prevalence of the 6A allele in the MMP-3 polymorphism at 90,8% signifying the participants' predominance of the 6A/6A genotype. None of the women exhibited the 5A/5A genotype. For MMP-9 polymorphism, the majority was characterized by the C allele, with the CC homozygous genotype being most prevalent at 85,8%. The allele frequency distributions for MMP-3 and MMP-9 polymorphisms adhered to the principles of Hardy-Weinberg equilibrium. 60% pregnant women had genotype 6A/6A of MMP-3 polymorphism combined with CC genotype of MMP-9 polymorphism. Conclusions: The proportion of pregnant women carrying homozygous 6A/6A genotype for MMP-3 polymorphism and CC genotype for MMP-9 polymorphism accounted for the majority (81,7% and 73,35%, respectively
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Keywords
Pregnant women, Matrix metalloproteinase (MMP), MMP-3 polymorphism, MMP-9 polymorphism
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