ĐÁNH GIÁ THỜI GIAN SỐNG THÊM Ở BỆNH NHÂN XƠ GAN MẤT BÙ DO VIÊM GAN VIRUS B TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

This study was conducted at National Hospital for Tropical Diseases to evaluate the overall survive and prognostic factors related to mortality during 90 days of following up. Materia and methods: 149 decompensated liver cirrhosis patients caused by hepatitis B virus infection were enrolled in the study. Kaplan Meier was used to estimate the survival, Log Rank test using for comparison of survival time between the two groups. Results: The overall survival at 90 days of following up was 32.2% and the mean survival time was 68.65±2.71 days. There was a significant difference in the mean survival time between bleeding from esophageal varices and without bleeding group (42.2±12.1 vs 70.4±2.7 days, p = 0.006), between GOT≤200U/L and GOT>200U/L group (76.0±3.4 vs 60.6±4.1 days, p=0.002), between direct Bilirubin ≤ 51µmol/l and > 51 µmol/l group (84.3±2.9 vs 61.2±3.5 days, p=0.000), between total Bilirubin ≤ 170 µmol/l and >170 µmol/l (79.8±3.1 vs 58.8±3.9 days, p=0.000). The Cox regression model showed that bleeding from esophageal varices and direct bilirubin > 51µmol/l were the prognosis factors related to mortality over 90 days period after admission with the HR was 3,948 and 4,484, respectively (p< 0.05). Conclusion: In decompensated cirrhosis patients, it is necessary to follow up patients to early detect and preventively treat for oesophagial varices bleeding. Transaminase and serum bilirubin should be tested periodically for timely patients prognosis.