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DETECTION OF CARBAPENEMASE ENCODING GENES IN PEUDOMONAS AERUGINOSA ISOLATES WITH PHENOTYPIC NON-RESISTANT PROFILE
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Abstract
Objectives: The escalating prevalence of multidrug-resistant Pseudomonas aeruginosa presents a formidable challenge in effectively treating infections attributed to this bacterium. This research aimed to detect carbapenemase encoding genes within P. aeruginosa strains that manifest non-resistance to conventional antibiotics. Materials and methods: In this cross-sectional study, 24 P. aeruginosa strains displaying non-resistance to the tested antibiotics were examined. Multiplex Real-time PCR was employed to identify specific carbapenemase encoding genes within these strains. Results: Out of the 24 tested P. aeruginosa strains, four were identified as carriers of carbapenemase genes. Notably, two strains harboured the blaKPC gene, one carried the blaNDM gene, and another carried the blaOXA-48 gene. Conclusion: The combination of bacterial drug resistance phenotypes and genotypes is imperative for the comprehensive management and surveillance of antibiotic resistance in P. aeruginosa.
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Keywords
P. aeruginosa, carbapenemase genes, Hai Phong International General Hospital.
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