KHẢO SÁT MỨC ĐỘ TƯƠNG TÁC THUỐC TRONG CÁC ĐƠN THUỐC ĐIỀU TRỊ ĐÁI THÁO ĐƯỜNG TUÝP 2 TẠI BỆNH VIỆN THỐNG NHẤT NĂM 2023

Abstract

Background: Diabetes mellitus is a chronic disease with a complex course that increases the risk of death from chronic diseases worldwide. Drug combination in treatment is inevitable, especially in the presence of multiple diseases and symptoms. Therefore, it is necessary to survey the level of drug interactions in diabetes mellitus treatment prescriptions. Objective: Determine the rate and severity of drug interactions occurring in prescriptions and medical records at Thong Nhat Hospital in 2023. Materials and method: A cross-sectional study based on prescriptions of type 2 diabetes mellitus patients who visited Thong Nhat Hospital from March to August 2023. The severity of drug interactions in the prescriptions was assessed on Medscape and Drugs.com. Results: A survey of 400 medical records recorded that the average age of the survey sample at Thong Nhat Hospital was 73.9 ± 8.5, the female: male ratio was 1.31:1, 96.8% of diabetic patients. Type 2 has at least one comorbidity. Among comorbid diseases, hypertension and dyslipidemia account for the highest rates with 87.3% and 72.5% of patients, respectively. Besides, the majority of patients have a glomerular filtration index above 60 mL/min/1.73 m2, accounting for 67.3%. Regarding diabetes drug interactions, moderate synergistic interactions are the most common type of interaction, accounting for 99.3% of the total interactions. Insulin is the drug with the highest frequency of drug interactions, accounting for 98.6% of all drug interactions. Drug interactions between diabetes drugs and other drugs appear quite commonly such as amlodipine - metformin at a rate of 17.7% of the total prescriptions, followed by drug interactions between losartan - insulin at 14.9% and ibesartan – insulin accounts for 10.6% of total prescriptions.