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LEFT ATRIAL STRAIN IN PATIENTS WITH END-STAGE CHRONIC KIDNEY DISEASE BEFORE AND AFTER KIDNEY TRANSPLANTATION
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Abstract
Background: Evaluation of changes in some morphology and left atrial strain in patients with end-stage chronic kidney disease before and after kidney transplantation. Methods: This was a prospective, single-center, consecutive study enrolling 40 patients with ESRD undergoing living - donor kidney transplantation, at Hospital 103 from from November 2022 to May 2023. Patients were followed up at baseline, and 1 month after KTX. Age- and gender-matched healthy people without any chronic diseases were enrolled as controls Results: LAD and LAVi in the end-stage chronic kidney disease group were higher than the control group (LAD: 50.8 ± 9.3 mm vs. 44.4 ± 8.5 mm, p < 0, 01), (LAVi: 30.3 ± 15.0 ml and 15.9 ± 6.7 ml, p < 0.01). Left atrial strain (LASr, LAScd, LASct) in the 4-chamber and 2-chamber views in the disease group were significantly decreased compared to the control group (p < 0.01). LASr was correlated with LAD (r = - 0.42, p < 0.01), EF (r = 0.3, p < 0.01), and Dd (r = - 0.36, p < 0.01), Ds (r = - 0.41, p < 0.01). After renal transplantation, LAD was decreased (50.8 ± 9.3 mm vs. 45.1 ± 5.8 mm, p < 0.01), left atrial strain was improved after 1 month (LASr_4C: 32.8 ± 11.7 % and 48 ± 9.9 %, p < 0.01), (LAScd_4C: -17.6 ± 8.5 % and -26.2 ± 7.0 %, p < 0.01), (LASct_4C: -15.2 ± 8.2 % and -19.6 ± 9.5 %, p < 0.01). Conclusions: Left atrial size in the end-stage chronic kidney disease patients was higher and left atrial strain (LASr, LAScd, LASct) was reduced compared to the control group. LASr in the pre-transplant disease group was positively correlated with LAD, EF and negatively correlated with Dd, Ds. After kidney transplantation, left atrial size decreased and, left atrial strain improved after 1 month.
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Keywords
Chronic Kidney Disease, Kidney transplantation, Left atrial strain.
References
2. Gan GCH, Ferkh A, Boyd A, Thomas L. Left atrial function: evaluation by strain analysis. Cardiovasc Diagn Ther. 2018;8(1):29-46.
3. Tripepi G, Benedetto FA, Mallamaci F, Tripepi R, Malatino L, Zoccali C. Left atrial volume monitoring and cardiovascular risk in patients with end-stage renal disease: a prospective cohort study. J Am Soc Nephrol. 2007;18(4):1316-22.
4. Donal E, Lip GY, Galderisi M, Goette A, Shah D, Marwan M, et al. EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation. Eur Heart J Cardiovasc Imaging. 2016;17(4):355-83.
5. Kim SJ, Han SH, Park JT, Kim JK, Oh HJ, Yoo DE, et al. Left atrial volume is an independent predictor of mortality in CAPD patients. Nephrol Dial Transplant. 2011;26(11):3732-9.
6. Calleja AM, Rakowski H, Williams LK, Jamorski M, Chan CT, Carasso S. Left atrial and ventricular systolic and diastolic myocardial mechanics in patients with end-stage renal disease. Echocardiography. 2016;33(10):1495-503.
7. Yildirim U, Akcay M, Coksevim M, Turkmen E, Gulel O. Comparison of left atrial deformation parameters between renal transplant and hemodialysis patients. Cardiovasc Ultrasound. 2022; 20(1):5.
8. Tanasa A, Burlacu A, Popa C, Kanbay M, Brinza C, Macovei L, et al. A Systematic Review on the Correlations between Left Atrial Strain and Cardiovascular Outcomes in Chronic Kidney Disease Patients. Diagnostics (Basel). 2021;11(4).