ẢNH HƯỞNG CỦA EPSTEIN-BARR VIRUS ĐẾN SỰ BIỂU HIỆN GEN HK2 TRÊN BỆNH NHÂN U LYMPHO

Abstract

Lymphoma is a malignacy originating from the lymphatic hematopoietic system with high morbidity and mortality on the world and associated with Epstein-Barr virus (EBV), a member belongs to herpesvirus family. Overexpression of Hexokinase 2 (HK2) showed evidence important role in tumor progression and development. No database displayed HK2 expression related to EBV in peripheral blood of lymphoma patients. Therefore, our study evaluated the effect of EBV on the HK2 expression in the peripheral blood of 39 lymphoma patients who was newly diagnosis at Bach Mai hospital, Hanoi and compared with 14 healthy control. Our results detected 18/39 (46.2%) positive with EBV by PCR and electrophoresis method, HK2 expression were measured by qPCR. We found HK2 down expression in peripheral blood of lymphoma groups compared with healthy individuals. In particular, HK2 expression was decreased in EBV-positive T-cell lymphoma (p=0.03) and EBV-negative B-cell lymphoma (p=0.001), both in Non-Hodgkin lymphoma (p=0.003). This suggested that EBV is closely related to the HK2 expression in B- and T-lymphomas; HK2 and EBV expression in the peripheral blood of NHL patients should be more considered in the further studies.