MỐI LIÊN QUAN GIỮA KHÁNG THỂ ANTI-SMITH VÀ ĐẶC ĐIỂM LÂM SÀNG, MIỄN DỊCH CỦA BỆNH LUPUS BAN ĐỎ HỆ THỐNG TRẺ EM

Abstract

Objectives: The objective is to contrast the clinical and immunological characteristics of two groups of pediatric systemic lupus erythematosus patients, one with and one without anti-Smith antibodies. Subjects and methods: This cross-sectional study involved 83 pediatric patients newly diagnosed with systemic lupus erythematosus at the Pediatric Centre of Bach Mai Hospital. Results: Among the participants, 43,4% tested positive for anti-Smith antibodies, with an average age of 13,1 ± 2,4 years and a female-to-male ratio of 11:1. The prevalence rates of fever, hematological, neurological, dermatological, mucosal, serosal, joint, and renal manifestations, as well as the presence of anti-double-stranded DNA antibodies and low complement levels were 47,2%, 50,0%, 11,1%, 50,0%, 22,2%, 33,3%, 58,3%, 94,4%, and 86,1%, respectively. No significant discrepancies were observed in the clinical presentations between the two clusters based on the presence or absence of anti-Smith antibodies. The prevalence of positive antiphospholipid antibodies in the anti-Sm antibody-positive lupus patient group (41,7%) was higher compared to that in the anti-Sm antibody-negative lupus patient group (19,1%) (p < 0,05).