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Date Published: 11/09/2021
Abstract Views: 186
Views PDF: 148
DOI: https://doi.org/10.51298/vmj.v506i1-2.990
Issue
Vol. 506 No. 1-2 (2021): Vietnam Medical Journal
Section
Các bài báo
How to Cite
Viet Quang Hien, N. ., Hoang Duy Minh, L. ., Thi Dieu Ngan, P. ., Gia Vinh, L. ., Viet Quang, N. ., Thi Thuy Hoa, P. ., & Thi Cam Ha, C. . (2021). SAFETY AND EFFICACY OF STEM CELL THERAPY FOR TREATMENT SEVERE TRAUMATIC BRAIN INJURY. Vietnam Medical Journal, 506(1-2). https://doi.org/10.51298/vmj.v506i1-2.990

SAFETY AND EFFICACY OF STEM CELL THERAPY FOR TREATMENT SEVERE TRAUMATIC BRAIN INJURY

Nguyen Viet Quang Hien1, Le Hoang Duy Minh2, Phan Thi Dieu Ngan2, Le Gia Vinh3, Nguyen Viet Quang1, Phan Thi Thuy Hoa1, Che Thi Cam Ha2,
1 Hue Central Hospital
2 Hue University
3 Vietnam Medical Association

Main Article Content

Abstract

Traumatic brain injury (TBI) is a complicated topic.TBI has expensive treatment, sequelae, high mortality and efficient therapeutic strategies for TBI are urgently needed. Patients with severe TBI account for 10% of all traumatic brain injury patients, but more than 80% of patients who die from traumatic brain injury are in this group of patients. That proves the danger of severe TBI. Mesenchymal stem cells (MSCs) are multipotent cells with high proliferative and self-renewal capacities, as well as immunomodulatory and neuroregenerative effects. MSCshave been shown to treat TBI and significantly reduce inflammation of injured tissue. In the present study, we evaluated the quality and effectiveness of mesenchymal stem cell transplantation with the graft dose of 9x106cells/kg. Clinical indexes (Pulse, temperature, SBP, HATTr, HATTB, GCS) and subclinical (Hepatic index, kidney, cortisol, lactate, glucose, hematological index, respiratory index) were monitored on 60 patients within 6 months.


The results showed that the recovery journey is different for every person with the graft dose of 6-9x106 cells/kg, but there were no adverse complications for the patients, the clinical and paraclinical indicators were stable. No significant side effects were observed during the trial as well as after 6 months of treatment. The MSC transfusions significantly increased the life quality patients; reduced brain damage  and increased HSC counts. Inflammatory cytokines (IL-6) levels decreased and GCS increased in the MSC transfusion group, indicating that the patient's health improved.

Article Details

Keywords

Traumatic brain injury, mesenchymal stem cell, mononuclear cells, transplantation, neuroimmunity, anti-inflammation

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