HIỆU QUẢ CỦA FIBRIN GIÀU TIỂU CẦU CẢI TIẾN (A-PRF+) TRONG ĐIỀU TRỊ VIÊM NHA CHU CÓ TIÊU XƯƠNG THEO CHIỀU NGANG

Abstract

Objective: Evaluate the effectiveness of improving clinical and microbiological parameters of advanced platelet-rich fibrin plus(A-PRF+) in the treatment of periodontitis with horizontal bone loss. Subjects and methods: Clinical intervention study, split-mouth design with 20 teeth affected by periodontal pockets with horizontal bone loss, indicated for surgical treatment in 10 patients: flap surgery combined with A-PRF+ graft (VLS_A-PRF+) group and flap surgery alone (VLS) group. Comparison of clinical parameters: plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment loss (CAL) before surgery and 1 month post-treatment. Comparison of Fusobacterium nucleatum (Fn), Tannerella forsythia (Tf) and Porphyromonas gingivalis (Pg) bacteria levels in periodontal pockets 1 week, and 1 month after surgery using Real-time PCR. Results: After 1 month, PPD and CAL in VLS_A-PRF+ group and VLS group were significantly lower compared to baseline (p<0.001). The reduction in PPD in VLS_A-PRF+ group (3.10 ± 0.88 mm) was significantly higher than in VLS group (1.7 ± 0.48 mm) (p<0.001), however, the reduction in CAL in VLS_A-PRF+ group (1.70 ± 1.42 mm) was not significantly different from VLS group (1.50 ± 1.43 mm) (p>0.05). At 1 week and 1 month, the levels of Fn, Tf, Pg bacteria decreased in both groups compared to baseline, with a higher reduction in VLS_A-PRF+ group, but the difference was not statistically significant (p>0.05). Conclusion: Using A-PRF+ effectively supports the reduction of probing pocket depth when combined with flap surgery in the treatment of periodontitis with horizontal bone loss.