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PREDICTIVE VALUE OF THE TYG INDEX FOR DIABETIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT BACH MAI HOSPITAL
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Abstract
Background: Diabetic kidney disease (DKD) is one of the chronic microvascular complications of type 2 diabetes mellitus (T2DM). The triglyceride-glucose (TyG) index has been proposed as an early predictive marker of renal impairment. Objective: To evaluate and analyze the relationship between the TyG index and the presence of kidney injury in patients with type 2 diabetes. Subjects and Methods: This was a cross-sectional descriptive study including 155 patients with T2DM treated at Bach Mai Hospital during 2024–2025. Pearson correlation analysis, t-test, Mann–Whitney test, and ROC curve analysis were applied. Results: The mean TyG index was significantly higher in patients with renal damage compared to those without (p < 0.01). TyG showed a weak positive correlation with estimated glomerular filtration rate (eGFR) (r = 0.248; p = 0.002), a negative correlation with serum creatinine (r = –0.187; p = 0.020), and no significant correlation with proteinuria. The ROC curve yielded an area under the curve (AUC) of 0.712, with an optimal cut-off value of TyG ≥ 5.31 (sensitivity: 53.6%, specificity: 71.4%). Patients with TyG ≥ 5.31 had a nearly 3-fold higher risk of kidney damage (OR = 2.88). Conclusion: The TyG index is significantly associated with markers of renal injury and may serve as a useful tool in assessing the risk of diabetic kidney disease in patients with type 2 diabetes.
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Keywords
TyG, type 2 diabetes mellitus, kidney injury, proteinuria, eGFR, ROC.
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