Anril gene polymorphism rs1333040 and the association with severity of coronary artery stenosis in patients with chronic coronary syndrome: A multicenter study

Tóm tắt

Introduction: Several studies have indicated that the rs1333040 polymorphism of the ANRIL gene is associated with the severity of coronary artery stenosis; however, data remain inconsistent, particularly among patients with chronic coronary syndrome. Objective: To determine the characteristics of the rs1333040 polymorphism of the ANRIL gene and its association with the severity of coronary artery stenosis. Materials and methods: This cross-sectional descriptive analytical study was conducted on 79 patients diagnosed with chronic coronary syndrome treated at Can Tho University of Medicine and Pharmacy Hospital, Can Tho Central General Hospital, and Can Tho Cardiovascular Hospital from June 2024 to June 2025. Results: The mean age of the 79 patients included in the study was 67.35 ± 8.86 years, with the majority aged ≥ 60 years. The gender distribution was nearly equal. Regarding lifestyle, more than two-thirds of patients were sedentary, and half reported tobacco smoking. Hypertension was common among patients; approximately half were overweight or obese, had dyslipidemia, and one-third had diabetes mellitus. Genotype frequencies were 41.3% TT and 58.7% TC. The T and C allele frequencies were 72.2% and 27.8%, respectively. The TT genotype group exhibited significantly higher proportions of moderate (84.8% vs. 65.9%) and severe (14.3% vs. 0%) Gensini scores compared to the TC genotype group (p < 0.001). Similarly, the T allele was associated with significantly higher rates of moderate and severe Gensini scores compared to the C allele (p = 0.012). Conclusion: The T allele and TT genotype of the rs1333040 polymorphism in the ANRIL gene were significantly associated with higher proportions of moderate and severe coronary artery stenosis according to the Gensini score compared with the C allele and TC genotype in patients with chronic coronary syndrome.