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Ngày xuất bản: 24/11/2025
Số lượt xem tóm tắt: 64
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DOI: https://doi.org/10.51298/vmj.v556i2.16207
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Tập 556 Số 2 (2025): Vietnam Medical Journal
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Thanh , L., Sang, . H. V., Lac , T. K. N., Nguyen , N. K. N., & Hung , G. T. (2025). Treatment outcomes of melasma using picosecond Nd: YAG 1064nm laser at Can Tho Dermatology Hospital. Tạp Chí Y học Việt Nam, 556(2). https://doi.org/10.51298/vmj.v556i2.16207

Treatment outcomes of melasma using picosecond Nd: YAG 1064nm laser at Can Tho Dermatology Hospital

Thanh Lam1, Sang Huynh Van1, Lac Thi Kim Ngan2, Nguyen Ngoc Kim Ngan3, Hung Gia Tran2,
1 Can Tho University of Medicine and Pharmacy
2 Department of Dermato-Venereology, Faculty of Medicine, Can Tho University of Medicine and Pharmacy
3 Hong Bang International University

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Tóm tắt

Objective: To evaluate the efficacy of the picosecond Nd:YAG 1064 nm laser in treating melasma at Can Tho Dermatology Hospital from 2024 to 2025.  Research object and Method: A cross-sectional study was conducted on 55 patients diagnosed with melasma at the Can Tho Dermatology Hospital from July 2024 to May 2025. Melasma was evaluated using the Melasma Area and Severity Index (MASI) score, varied from 0 to 48, of which mild level < 5.5, average > 5.5 - < 8.7, heavy > 8.7 - < 13.1, very heavy > 13.1 – 48. Clinical improvement was assessed every 4 weeks (re-examination and subsequent treatment) at 4, 8, 12, 16, and 20 weeks. Results: The mean Melasma Area and Severity Index (MASI) score decreased progressively. At baseline (T0), the mean MASI score was 10.49 ± 2.49. After 4 weeks (T1), it reduced to 8.80 ± 2.56, followed by 7.07 ± 2.14 at 8 weeks (T2), 5.76 ± 1.61 at 12 weeks (T3), 4.40 ± 1.21 at 16 weeks (T4), and 3.26 ± 0.70 at 20 weeks (T5). These reductions were statistically significant (p < 0.01). The most common side effects at T5 were transient tingling (45.5%), dry skin (36.4%), pruritus (36.4%), and erythema (36.4%), all of which resolved spontaneously. The incidence of new lesions decreased over time, and no new lesions were reported at T5. Conclusion: These findings suggest that picosecond Nd:YAG 1064 nm laser demonstrated high efficacy and safety in treating melasma, with significant reductions in MASI scores, improved clinical severity, and minimal transient side effects. 

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Từ khóa

melasma, picosecond laser, Nd:YAG 1064nm laser, MASI

Tài liệu tham khảo

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