Association of the left atrioventricular coupling index with clinical and laboratory characteristics in patients with acute myocardial infarction undergoing percutaneous coronary intervention

Tóm tắt

Objective: To investigate the relationship between left atrioventricular coupling and clinical, laboratory characteristics in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Subjects and methods: A total of 170 participants were enrolled, including 120 patients with AMI undergoing PCI and 50 control subjects without coronary artery disease, matched for age, sex, and cardiovascular risk factors. Three-dimensional echocardiography (3DE) with left atrioventricular coupling index (LACI) measurement was performed in both groups. In the AMI group, echocardiography was conducted at baseline (within 24 hours of admission) and at 7 days, 1 month, 3 months, 6 months, 9 months, and 12 months after PCI. Results: LACI was significantly higher in the AMI group compared with controls (19.2 ± 7.3% vs. 15.1 ± 6.4%; p < 0.001). LACI was higher in patients with multivessel disease than in those with single-vessel disease. In patients with AMI, LACI was positively correlated with age (r = 0.2; p = 0.034), TIMI risk score (r = 0.38; p < 0.001), GRACE score (r = 0.27; p = 0.003), NT-Pro BNP level (r = 0.27; p = 0.006), and left atrial volume index (LAVI; r = 0.42; p < 0.001). In contrast, LACI showed inverse correlations with left atrial ejection fraction (LAEF; r = -0.51; p < 0.001), LASr (r = -0.41; p < 0.001), LAScd (r = -0.27; p = 0.003), LASct (r = -0.43; p < 0.001), and LVGLS (r = -0.23; p = 0.011). Conclusion: Patients with AMI undergoing PCI exhibited higher LACI compared with controls. In patients with AMI, LACI showed positive associations with age, TIMI risk score, GRACE score, NT-Pro BNP level and LAVI; whereas it was inversely associated with LAEF, left atrial strain, and LVGLS.