NHẬN XÉT MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN BỆNH GAN NHIỄM MỠ LIÊN QUAN RỐI LOẠN CHUYỂN HÓA Ở BỆNH NHÂN CÓ BỆNH ĐỘNG MẠCH CHI DƯỚI MẠN TÍNH

Abstract

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common disease worldwide, the rate of which has been shown to increase in patients with peripheral artery disease. The study aims to evaluate some factors related to metabolic dysfunction-associated steatotic liver disease in patients with peripheral artery disease. Method: A cross-sectional description study, data was collecected on 124 patients with peripheral artery disease who underwent ultrasound assessment of metabolic dysfunction-associated steatotic liver disease at the Vietnam Heart Institute - Bach Mai Hospital from August 2024 to August 2025. Results: A 124 patient study in which the male/female ratio was 1.5/1, the average age was 74.1±11.38 years old with 85.4% of patients over 65 years old. The rate of metabolic dysfunction-associated steatotic was 41.1%, mainly grade 1 with 29%. The rate of metabolic dysfunction-associated steatotic was higher with later stages of peripheral artery disease (53.7% and 57.7% in Rutherford grades 5 and 6, difference p < 0.05). The metabolic dysfunction-associated steatotic liver disease increased in patients with diabetes (OR: 2.92, p: 0.06), dyslipidemia (OR: 2.707, p: 0.01), metabolic syndrome (OR: 3.17, p: 0.005). In metabolic dysfunction-associated steatotic liver disease patient, the cholesterol index was higher (4.49 ± 1.2 vs 3.54 ± 1.26), the triglyceride index was higher (2.3 ± 1.33 vs 1.47 ± 0.96), and the LDL index was higher (2.79 ± 1.03 vs 2.06 ± 1.03). The differences had p < 0.05. Conclusion: The rate of MASLD in patients with PAD  is relatively high. Factors such as increased waist circumference and triglyceride concentration above 1.7 are 2 independent risk factors in this group of patients