MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN HỘI CHỨNG SUY HÔ HẤP Ở BỆNH NHÂN NGỘ ĐỘC CẤP GLUFOSINAT

Abstract

Objective: Comments on some factors related to respiratory failure syndrome in patients with acute glufosinat poisoning treated at the Poison Control Center, Bach Mai Hospital. Method: A prospective study included 87 patients with Glufosionat poisoning treated at the Poison Control Center of Bach Mai Hospital. Results: In this retrospective analysis, age, ingested dose, and time to hospital admission were identified as prognostic factors for respiratory failure. Patients aged ≥53,5 years had a 7,7-fold higher risk (OR = 7,729; CI 95%: 2,648–22,557; p < 0,001), while a dose ≥14,25 g predicted respiratory failure with 100% sensitivity and 47% specificity. Delayed hospital admission was also significantly associated with respiratory failure (p = 0.039). Clinical parameters including lower GCS on admission, bradycardia on day 1–2, higher PREP and SIRS scores were significant predictors (all p < 0.001). Univariate regression further revealed that PREP ≥41,5 (OR = 52,4; 95% CI: 12,33–223,34; p < 0,001), HCO₃⁻ ≤19.7 mmol/L (OR = 12,0, 95% CI: 3,48–41,35; p < 0.001), WBC >10.1 G/L (OR =9,6; CI 95%: 3,07 - 30,03; p < 0,001)), and NH₃ >68,3 µmol/L (OR = 16,87; CI 95%: 4,20-67,74; p < 0,001) were strongly associated with increased risk of respiratory failure. Conclusion: The prognostic factors for respiratory failure in patients with glufosinat poisoning were: age, ingested dose, time from ingestion to hospital admission, Glasgow Coma Scale on admission, PREP score, SIRS score, bradycardia, initial white blood cell count, ammonia level, and bicarbonate (HCO₃⁻)