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THE VALUE OF RETICULOCYTE HEMOGLOBIN EQUIVALENT (RET-HE) INDEX IN DIAGNOSING IRON DEFICIENCY ANEMIA IN PATIENTS WITH END-STAGE CHRONIC KIDNEY DISEASE ON REGULAR HEMODIALYSIS
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Abstract
Introduction: End-stage chronic kidney disease (ESCRD) is a prevalent health issue requiring close monitoring. Iron deficiency anemia (IDA) plays a significant role in the management of CKD. The reticulocyte hemoglobin index (Ret-He) provides a rapid and more accurate assessment of iron status in CKD patients compared to other indirect methods. Objective: To determine the value of the Ret-He index in diagnosing IDA in patients with end-stage CKD on regular hemodialysis. Subjects and Methods: This was a descriptive case series study of anemic patients with end-stage CKD on regular hemodialysis. The study variables included age, gender, anemia status, complete blood count, Ret-He, serum iron, serum ferritin, and transferrin saturation (TSAT). The Ret-He index was compared between the IDA and non-IDA groups. Results: A total of 126 subjects were included, of which 86 had non-IDA and 40 had IDA. The mean Ret-He values and standard deviations of the non-IDA and IDA groups were 32.25 pg ±3.567 and 29.19 pg ±3.550, respectively. This difference was statistically significant with p <0.0001. The diagnostic value of Ret-He for IDA at a cutoff of 32 pg was 80.0% sensitivity and 62.8% specificity. Conclusion: Ret-He has a moderate value in diagnosing IDA, with a sensitivity of 80.0% and a specificity of 62.8% at a cutoff of ≤32 pg.
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Keywords
End-stage chronic kidney disease, iron deficiency anemia, Ret-He index, reticulocyte
References
2. Dinh NH, Cheanh Beaupha SM and Tran LTaJBN. The validity of reticulocyte hemoglobin content and percentage of hypochromic red blood cells for screening iron-deficiency anemia among patients with end-stage renal disease: a retrospective analysis. 2020; 21(1):1-7.
3. Nguyễn MT. Giá trị của huyết sắc tố hồng cầu lưới trong theo dõi và điều trị thiếu máu ở bệnh nhân lọc máu chu/Nguyễn Minh Thọ. 2021.
4. Rovani F, Nurulita A, Arif MJIJOCP and Laboratory M. Analysis of ret-he in chronic kidney disease patients at Dr. Wahidin Sudirohusodo Hospital, Makassar. 2018; 25(1):7-10.
5. Kim J, Ihm C and Kim HJIJOLH. Evaluation of reticulocyte haemoglobin content as marker of iron deficiency and predictor of response to intravenous iron in haemodialysis patients. 2008; 30(1):46-52.
6. Dinh NH, Cheanh Beaupha SM and Tran LTaJBN. The validity of reticulocyte hemoglobin content and percentage of hypochromic red blood cells for screening iron-deficiency anemia among patients with end-stage renal disease: a retrospective analysis. 2020; 21:1-7.
7. Brugnara C, Schiller B, Moran JJC and Haematology L. Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron‐deficient states. 2006; 28(5):303-308.
8. Miwa N, Akiba T, Kimata N, et al. Usefulness of measuring reticulocyte hemoglobin equivalent in the management of haemodialysis patients with iron deficiency. 2010; 32(2):248-255.