XÁC ĐỊNH NỒNG ĐỘ TRUNG BÌNH Mg++ TRONG MÁU TRƯỚC VÀ SAU KHI DÙNG MAGNESIUM SULFATE ĐỂ PHÒNG NGỪA SẢN GIẬT TẠI BỆNH VIỆN HÙNG VƯƠNG

Abstract

Background: Recommendations for magnesium sulfate (MgSO₄) dosage to prevent eclampsia and minimize side effects are still inconsistent because of the different physical conditions and weights of the population in each country. Objective: Determine the average concentration of Mg⁺⁺ in the blood of pregnant women with severe preeclampsia at Hung Vuong Hospital 3 times: before taking MgSO₄, 30 minutes after taking a loading dose of 4.5g, and after taking a loading dose of 4.5g 6 hours with a maintenance dose of 1g/hour. Method: Cross-sectional study, blood samples taken 3 times, the survey of Mg⁺⁺ concentration in blood from 0 to 6 hours on 64 pregnant women with severe preeclampsia treated with MgSO₄ at the emergency department of Hung Vuong Hospital from 11/2023 to 4/2024. Results: The concentration of Mg⁺⁺ in the blood before MgSO₄ treatment was 0.75 ± 0.13 mmol/l (95% CI: 0.71 - 0.78), after 30 minutes of taking a loading dose of 4.5g it was 1.65 ± 0.32 mmol/l (95% CI: 1.57 - 1.72) and after 6 hours loading dose with a maintenance dose of 1g/hour was 1.6 ± 0.34 mmol/l (95% CI: 1.52 - 1.69). After the loading dose, the rate of 17.2% had at least once achieved a blood Mg⁺⁺ concentration of 2 mmol/l after 6 hours. Conclusion: No cases of eclampsia occurred during the study period in patients with severe preeclampsia with the MgSO₄ regimen of induction 4.5g and maintenance 1g/hour. However, if the minimum eclampsia prevention threshold of 2 mmol/l is chosen, 17.2% will be achieved after the loading dose. Therefore, further research is needed to adjust the appropriate attack dose of MgSO₄ for the treatment of pregnant women with severe preeclampsia.