NỒNG ĐỘ VITAMIN B12 VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN BỆNH THẬN MẠN GIAI ĐOẠN CUỐI LỌC MÁU ĐỊNH KỲ

Abstract

Background: Anemia is a common problem in chronic kidney disease (CKD), mainly caused by decreased erythropoietin production. Vitamin B12 deficiency is one of the causes of more severe anemia, and less responsive to erythropoietin. Objectives: to determine the vitamin B12 level and some related factors in patients with end-stage kidney disease (ESKD) undergoing hemodialysis. Subjects and methods: A cross-sectional descriptive study was conducted on 104 patients with ESKD on hemodialysis at Bac Lieu General Hospital, from 07/2023 to 02/2024. Results: The median vitamin B12 level in the patients was 584.0 pg/ml (lowest 163.0, highest 1768.0 pg/ml). There was 30.7% of patients had decreased vitamin B12 level. Patients with hemodialysis vintage ≥60 months had lower vitamin B12 level (619.5 [309.0-823.5] pg/ml compared to 467.5 [259.0-736.0] pg/ml, p<0.05), and a higher proportion of vitamin B12 deficiency (42.9% compared to 23.6%, p<0.05) than the group with hemodialysis vintage <60 months. Patients with moderate to severe anemia had lower B12 levels than the group without anemia or mild anemia. Conclusion: Patients with ESKD undergoing hemodialysis had a high rate of vitamin B12 deficiency. There was a relationship between vitamin B12 and the dialysis vintage and the severity of anemia in patients.