Article Sidebar

pdf
Date Published: 10/07/2024
Abstract Views: 50
Views pdf: 12
DOI: https://doi.org/10.51298/vmj.v540i1.10312
Issue
Vol. 540 No. 1 (2024)
Section
Các bài báo
How to Cite
Lê, H. T. Q., Kha, H. N., Nguyễn, T. D., & Lâm, P. T. (2024). COMPARISON OF TERLIPRESSIN AND OCTREOTIDE COMBINED WITH VARICEAL LIGATION FOR THE TREATMENT OF ACUTE ESOPHAGEAL VARICEAL BLEEDING. Vietnam Medical Journal, 540(1). https://doi.org/10.51298/vmj.v540i1.10312

COMPARISON OF TERLIPRESSIN AND OCTREOTIDE COMBINED WITH VARICEAL LIGATION FOR THE TREATMENT OF ACUTE ESOPHAGEAL VARICEAL BLEEDING

Huỳnh Thảo Quyên Lê, Hữu Nhân Kha, Thị Diễm Nguyễn, Phước Thiện Lâm

Main Article Content

Abstract

Objectives: Comparison of treatment results of Terlipressin and Octreotide combined with rubber band ligation in cirrhotic patients with gastrointestinal bleeding due to ruptured esophageal varices at Can Tho Central General Hospital and Can Tho General Hospital. Materials and methods: Cross-sectional study with randomized intervention in cirrhotic patients with gastrointestinal bleeding due to ruptured esophageal varices from September 2022 to March 2024. Results: The number of blood transfusions in cirrhotic patients with gastrointestinal bleeding due to ruptured esophageal varices treated with drugs combined with rubber band ligation in the Telipressin group was 3.11 units less than in the Octreotide group position with 95% confidence interval ((-3.99 to -2.23), p < 0.01). Similarly, the group of patients treated with Terlipressin had a shorter hospital stay than the group of patients treated with Octreotide by 1.8 days with a 95% confidence interval ((-2.78 to -0.87), p = 0.002). The difference in mortality between the two groups of patients was not statistically significant. Conclusion: Terlipressin showed better treatment results than Octreotide in reducing the number of blood transfusions and number of hospital days. The mortality rate in both groups did not differ.

Article Details

Keywords

ruptured esophageal varices, Terlipressin, Octreotide, band ligation.

References

1. Huỳnh Thanh Trúc (2019), “Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và đánh giá kết quả điều trị vỡ giãn tĩnh mạch thực quản bằng thắt vòng cao su ở bệnh nhân xơ gan tại Bệnh viện Đa khoa Thành phố Cần Thơ”, Luận văn Tốt nghiệp Bác sĩ Chuyên khoa II, Trường Đại học Y Dược Cần Thơ, tr.51-72
2. Đặng Thị Hòa, cộng sự (2023), “Kết quả điều trị xuất huyết tiêu hóa cao do giãn vỡ tĩnh mạch thực quản ở bệnh nhân xơ gan bằng phương pháp thắt tĩnh mạch thực quản kết hợp Terlipressin”, Tạp chí Y Dược Thái Bình, 09, tr.04-02.
3. Brunati X, Ceriani R, Curioni R, Brunelli L, Repaci G, Morini L (1996), “Sclerotherapy alone vs scherotherapy plus terlipressin vs sclerotherapy plus octreotide in the treatment of acute variceal hemorrhage”, Hepatology, 24(4), pp.207A-210A.
4. Abid S., Jafri W., Hamid S., Salih M., Azam Z., Mumtaz, Abbas Z. (2009), “Terlipressin vs. octreotide in bleeding esophageal varices as an adjuvant therapy with endoscopic band ligation: a randomized double-blind placebo-controlled trial”, Official journal of the American College of Gastroenterology - ACG, 104(3), pp.617-623.
5. Trần Văn Thạch, Lê Thành Lý (2013), “Đánh giá hiệu quả cầm máu của thuốc somatostatin, octreotide, glypressin ở bệnh nhân chảy máu tiêu hoá do vỡ giãn tĩnh mạch thực quản trên bệnh nhân xơ gan mất bù”, Tạp chí Khoa học Tiêu hóa Việt Nam, 08(32), tr.2055-2061.
6. Asad M., Alam M.F. (2014), “A comparison of terlipressin and octreotide for the control of esophageal variceal bleeding in patients of liver cirrhosis”, Journal of Clinical and Experimental Hepatology, 4, pp.S86-S90.
7. Fatima A., Chachar A.Z.K., Ahmed S.I., Qaisera S. (2017), “Comparison of Terlipressin with Octreotide in Management of Acute Variceal Bleed in Patients with Liver Cirrhosis”, Journal of Rawalpindi Medical College, 21(3), pp.83-87.
8. Zhou X., Tripathi D., Song T., Shao L., Han B., Zhu J, Qi X. (2018), “Terlipressin for the treatment of acute variceal bleeding: a systematic review and meta-analysis of randomized controlled trials”, Medicine, 97(48), e13437.