ĐẶC ĐIỂM DỊCH TỄ VÀ NỘI TIẾT TỐ CỦA BỆNH NHÂN VÔ SINH NAM DO VI MẤT ĐOẠN AZF TRÊN NHIỄM SẮC THỂ Y

Abstract

Objective: Research on epidemiology and hormonal disorders characteristics in infertile males due to AZF microdeletion on the Y chromosome. Methods: Retrospective and prospective descriptive study at the Military Institute of Clinical Embryology and Histology. Patients diagnosed with sperm concentration less than 5 million/ml are prescribed a test to determine the AZF microdeletion mutation on the Y chromosome. Patients with AZF microdeletion are evaluated for clinical characteristics and assessment of reproductive hormonal levels including FSH, LH, testosterone, estradiol and prolactin. Results: Research on 395 patients with sperm concentration less than 5 million/ml found that Y chromosome AZF microdeletion was found in 46 patients, accounting for 11.65%. The most common is deletion in the AZFc region (45.65%). The mean right and left testicular volumes were 7.48 ± 3.67 ml and 7.57 ± 3.53 ml, with no statistically significant difference. The patient's serum FSH level elevated to 16.39 ± 12.97 mIU/ml. Meanwhile, the levels of other serum reproductive hormones including prolactin, estradiol and testosterone are within normal ranges. Comparing the severe oligospermic and azoospermic groups, it was found that FSH and LH levels in the azoospermic group were statistically significantly higher (p < 0.05). Conclusion: The incidence of microdeletion of the Y chromosome confined to AZF a,b,c and d regions is 11.65% in the group of severely decreased sperm concentration patients, among that, the most common microdeletion is in the AZFc region. In the group of patients with AZF microdeletion, FSH and LH levels in azoospermic patients were statistically significantly higher than in the group with severe oligospermia.