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Date Published: 22/07/2024
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DOI: https://doi.org/10.51298/vmj.v540i3.10499
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Vol. 540 No. 3 (2024)
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Các bài báo
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Vũ, Q. H., Phạm , V. T., Hoàng , X. S., & Ngô, T. H. (2024). INFLUENCE OF CYP3A5 GENE POLYMORPHISM ON TACROLIMUS PHARMACOKINETICS IN PATIENTS IN THE FIRST YEAR AFTER KIDNEY TRANSPLANTATION AT 103 MILITARY HOSPITAL. Vietnam Medical Journal, 540(3). https://doi.org/10.51298/vmj.v540i3.10499

INFLUENCE OF CYP3A5 GENE POLYMORPHISM ON TACROLIMUS PHARMACOKINETICS IN PATIENTS IN THE FIRST YEAR AFTER KIDNEY TRANSPLANTATION AT 103 MILITARY HOSPITAL

Quang Hợp Vũ, Văn Trân Phạm , Xuân Sử Hoàng , Thu Hằng Ngô

Main Article Content

Abstract

Objective: To evaluate the impact of CYP3A5 gene polymorphisms on the pharmacokinetics of tacrolimus in the first year after kidney transplantation. Subjects and methods: Retrospective study combined with prospective longitudinal follow-up, surveying 95 kidney transplant patients at Military Hospital 103 from March 2020 to March 2023, collecting information on tacrolimus dosage, CYP3A5 gene polymorphism test, tacrolimus trough concentration quantification. Result: Patients with the CYP3A5*1/*1 and CYP3A5*1/*3 genotypes received a higher mean dose of tacrolimus than patients with the CYP3A5*3/*3 genotype. Mean tacrolimus trough concentrations in renal transplant patients with CYP3A5*1/*1 and CYP3A5*1/*3 genotypes were lower than in patients with the CYP3A5*3/*3 genotype. The mean tacrolimus concentration/dose (C/D) ratio for patients with CYP3A5*1/*1, CYP3A5*1/*3 genotypes was lower than CYP3A5*3/*3. Conclusion: CYP3A5 gene polymorphisms strongly influence tacrolimus dose. Patients expressing CYP3A5 required a higher median tacrolimus dose than nonexpressing patients (CYP3A5*3/*3), while median tacrolimus concentrations and concentration-to-dose (C/D) ratios were lower in five patients. first after kidney transplant.

Article Details

Keywords

CYP3A5 genetic polymorphisms, Kidney transplant, tacrolimus.

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