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THE SERUM LEVEL OF IL-17, IL-23, TNF-α IN PSORIASIS PATIENTS TREATED BY NARROW BAND UVB WITH THE REGIMEN BASED ON MINIMAL ERYTHEMA DOSE
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Abstract
Purpose: To describe the serum levels of inflammatory cytokines (IL-17, IL-23 and TNF-α) in patients with psoriasis vulgaris treated by narrow-band UVB (NB-UVB) protocol based on minimum erythema dose (MED). Subjects and methods: Study on 62 patients with moderate to severe psoriasis vulgaris who were treated by NB-UVB with an initial dose calculated based on MED, with a frequency of 2-3 treatments per week until achieving PASI 75. We aim to measure the cytokine levels of patients before and after achieving PASI 75. The study was conducted at the National Hospital of Dermatology and Venereology, from January 2017 to June 2019. Results: The mean serum concentrations of IL-17, IL-23 and TNF-α were 6.41 ± 11.1, 16.38 ± 24.83 and 128.14 ± 350.45 UI/l, respectively. No correlation was found between any cytokine levels and baseline PASI or body mass index (BMI). We measure the serum level of cytokin 39/62 patients reached PASI 75 at the time of achieving PASI 75, IL-17 levels decreased significanly (p=0.013, 95% confidence), while IL-23 and TNF-α did not show significant difference. Conclusion: Treatment with NB-UVB is supposed to improve clinical and blood cytokine levels in patients with psoriasis vulgaris.
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Keywords
psoriasis vulgaris, inflammatory cytokines, narrow band UVB (NB-UVB), minimal erythema dose (MED
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