OUTCOMES OF PATIENTS WITH MEDIUM AND SEVERE PSORIASIS VULGARIS TREATED WITH NARROWBAND UVB
Main Article Content
Abstract
Objective: Evaluate the results of narrow-band UVB phototherapy in patients with moderate and severe psoriasis vulgaris, starting dose based on Fitzpatrick skin types. Subject and research methods: Clinical trial were conducted on 60 patients with moderate or severe psoriasis vulgaris aged 16 years and older, treated with narrow band ultraviolet rays (UVB-311nm),. First dose were based on the Fitzpatrick skin types. All patients were treated 2-3 times per week until reaching PASI75 or at the end of treatment 36th. Our study evaluated the decrease in PASI index before, during and after treatment. Result: At the end of our study, the results showed that the percentage reduction in the PASI was 64.9 ± 5.6. The rate of achieving PASI75 is 70% in the group of severe (21,43%)and moderate (78.57%) patients. The most common side effect is hyperpigmentation (95.1%). Conclusion: This study showed that NB-UVB 311 nm is a safe and effective method for moderate and severe psoriasis vulgaris.
Article Details
Keywords
: Psoriasis vulgaris, PASI, NB-UVB, Fitzpatrick skin types
References
2. Markham T, Rogers S, Collins P. Narrowband UV-B (TL-01) phototherapy vs oral 8-methoxypsoralen psoralen–UV-A for the treatment of chronic plaque psoriasis. Archives of dermatology. 2003;139(3):325-328.
3. Cheng Y, Liu GJ, Zhang M. Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis. Cochrane Database of Systematic Reviews. 2013;(10). Accessed April 22, 2024. https://www. cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009481.pub2/abstract
4. Foerster J, Boswell K, West J, et al. Narrowband UVB treatment is highly effective and causes a strong reduction in the use of steroid and other creams in psoriasis patients in clinical practice. PloS one. 2017;12(8):e0181813.
5. WOLFF K, Goldsmith L, Katz S, et al. IN GENERAL MEDICINE. Published online 2008. Accessed December 21, 2023. https:// jamanetwork.com/journals/jamadermatology/article-abstract/540790
6. Tanew A, Radakovic-Fijan S, Schemper M, Hönigsmann H. Narrowband UV-B phototherapy vs photochemotherapy in the treatment of chronic plaque-type psoriasis: a paired comparison study. Archives of dermatology. 1999;135(5):519-524.
7. Tâm HV. Điều trị bệnh vảy nến thông thường bằng UVB dải hẹp. \DJại Học Y Hà Nội. Published online 2015.
8. Yones SS, Palmer RA, Garibaldinos TT, Hawk JL. Randomized double-blind trial of the treatment of chronic plaque psoriasis: Efficacy of psoralen–uv-a therapy vs narrowband uv-b therapy. Archives of dermatology. 2006;142(7): 836-842.