Article Sidebar
Views PDF: 347
EVALUATE HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B WITH REAL-TIME TISSUE ELASTOGRAPHY
Main Article Content
Abstract
Objective: To determine the formula of the liver fibrosis index (LFI) for chronic hepatitis B (CHB) by real time tissue elastography and to validate the diagnostic accuracy of LFI the for hepatic fibrosis compared with liver biopsy and fibroscan. Subjects and methods: Thirty-two prospectively enrolled patients with chronic hepatitis B(CHB) underwent assess liver fibrosis index as well as perform fibroscan. The fibrosis stage according to Metavir score was diagnosed from pathological specimens obtained by ultrasound-guided liver biopsy. LFI score were compared with the pathological fibrosis stage diagnosis Metavir score and Fibroscan score, and the diagnostic performances of the indexes were compared. Results: Of 32 patients CHB were diagnosed by liver biopsy and quantified degree of fibrosis using Metavir score. Results showed the mean LFI score for different stages of fibrosis ranged from 1,45 ± 0,35 for F0 to 3,59 ± 0,51 for F4 and a direct correlation (r = 0,9119), was found to exist between LFI score and Metavir score (p<0,001). All LFI score and fibroscan have a value predicting liver fibrosis. Conclusion: we found that our newly developed LFI score is strongly correlated with histological fibrosis and fibroscan score, and real time elastography can be use as a method to predicting liver fibrosis
Article Details
Keywords
LFI, liver fibrosis
References
2. Thảng, H.T., Sinh thiết gan; Bệnh tiêu hóa - gan mật. 2002: Nhà xuất bản Y học.
3. MD Fankun Meng, M.Y.Z., MD Qi Zhang và et al, Noninvasive Evaluation of Liver Fibrosis Using Real-time Tissue Elastography and Transient Elastography (FibroScan). J Ultrasound Med, 2015. 34: p. 403–410 |0278-4297 |www.aium.org.
4. Kenji Fujimoto, M.K., Akiko Tonomura et al, Non- invasive evaluation method of the Liver fibrosis using Real time tissue Elastography - Usefulness of Judgment liver fibrosis stage by liver fibrosis index (LF index). Kanzo, 2010: p. 51:539- 541.
5. Fujimoto, K.M., Kudo M et al, Novel Image analysis method using ultrasound elastography for noninvasive evaluation of hepatic fibrosis in patient with chronic hepatitis C. Oncology, 2013. 84 Suppl 1: p. 3- 12.
6. Ferraioli G, T.C., Malfitano A et al, Performance of Real time strain elastography, transient elastography, and aspartate to platelet ratio index in the assessment of liver fibrosis in chronic hepatitis C. AJR Am J Roentgenol, 2012. 199: p. 19-25.