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Date Published: 13/09/2021
Abstract Views: 2272
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DOI: https://doi.org/10.51298/vmj.v505i2.1105
Issue
Vol. 505 No. 2 (2021)
Section
Các bài báo
How to Cite
Duy Mạnh, P. ., & Lê Huy, T. . (2021). RESULTS OF R-CHOP THERAPY IN DIFFUSE LARGE B-CELL NON-HODGKIN LYMPHOMA. Vietnam Medical Journal, 505(2). https://doi.org/10.51298/vmj.v505i2.1105

RESULTS OF R-CHOP THERAPY IN DIFFUSE LARGE B-CELL NON-HODGKIN LYMPHOMA

Phạm Duy Mạnh1, Trịnh Lê Huy1,2,
1 Hanoi Medical University
2 Hanoi Medical University Hospital

Main Article Content

Abstract

Objectives: To evaluate the treatment results of R-CHOP therapy in diffuse large B-cell non-hodgkin lymphoma. Patients and Methods: Descriptive, retrospective study on 35 patients treated with R-CHOP therapy at Hanoi Medical University Hospital from January 2015 to June 2021. Results: Clinicopathologic characteristics: Mean age was 57±13.7, male: female = 1.2:1. Nearly all patients had good performance status (94.3%). Peripheral lymph nodes detected was the most common presenting symptom (40%). A third of all patients had extralymph node disease (34.3%). 65.7% of all participants had elevated LDH enzyme before treatment. Treatment results and adverse events: complete response rate after 3 cycles was 28.6%, after 6 cycles was 82.9%. At the median follow up of 3 years, progression free survival rate was 87.8%. Neutropenia was the most common adverse events, in which only 5.8% had grade 3 or 4 toxicity. Conclusion: R-CHOP therapy was safe and highly effective in diffuse large B-cell lymphoma patients.

Article Details

Keywords

R-CHOP, Diffuse large B cell non Hodgkin lymphoma

References

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