Article Sidebar

PDF
Date Published: 13/09/2021
Abstract Views: 256
Views PDF: 209
DOI: https://doi.org/10.51298/vmj.v505i2.1106
Issue
Vol. 505 No. 2 (2021)
Section
Các bài báo
How to Cite
Văn Dương, P. ., & Thị Diệu Thúy, N. . (2021). THE CONCENTRATION OF SERUM 25(OH)D IN CHILDREN WITH BRONCHIOLITIS TREATED AT THE VIETNAM NATIONAL CHILDREN’S HOSPITAL. Vietnam Medical Journal, 505(2). https://doi.org/10.51298/vmj.v505i2.1106

THE CONCENTRATION OF SERUM 25(OH)D IN CHILDREN WITH BRONCHIOLITIS TREATED AT THE VIETNAM NATIONAL CHILDREN'S HOSPITAL

Phạm Văn Dương1,, Nguyễn Thị Diệu Thúy1
1 Hanoi Medical University

Main Article Content

Abstract

Vitamin D plays an important role in the immune system, including both innate and adaptive immunity. Objectives: To investigate the concentration of serum 25-(OH)D in children with bronchiolitis and the relationship between the concentration of serum 25-(OH)D and the severity of bronchiolitis. Subjects and methodS: 108 children with bronchiolitis treated at the Vietnam National Children's Hospital from July 2020 to June 2021. This was a descriptive cross-sectional study. Results: Mild bronchiolitis accounted for the highest rate with 62.04% and severe bronchiolitis was 15.74%. There was 14.82% children with bronchiolitis had low serum 25-(OH)D concentrations (< 50 nmol/l). 21.05% of group having serum 25-(OH)D concentrations less than 75 nmol/l suffered from severe bronchiolitis compared with 12.86% in group of serum 25-(OH)D concentrations equal or more than 75 nmol/l, with p=0.022. Conclusion: The serum 25-(OH)D concentration is associated with the severity of bronchiolitis in children.

Article Details

Keywords

Bronchiolitis, serum 25-(OH)D concentration, severity of disease

References

1. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The Burden of Respiratory Syncytial Virus Infection in Young Children. N Engl J Med. 2009 Feb 5;360(6):588–98.
2. Mogire RM, Mutua A, Kimita W, Kamau A, Bejon P, Pettifor JM, et al. Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis. Lancet Glob Health. 2020 Jan;8(1):e134–42.
3. Laillou A, Wieringa F, Tran TN, Van PT, Le BM, Fortin S, et al. Hypovitaminosis D and mild hypocalcaemia are highly prevalent among young Vietnamese children and women and related to low dietary intake. PloS One. 2013;8(5):e63979.
4. Poh BK, Rojroongwasinkul N, Le Nguyen BK, Ruzita AT, Yamborisut U, Hong TN, et al. 25-hydroxy-vitamin D demography and the risk of vitamin D insufficiency in the South East Asian nutrition surveys (SEANUTS). Asia Pac J Clin Nutr. 2016;25(3):538.
5. Barlow PG, Svoboda P, Mackellar A, Nash AA, York IA, Pohl J, et al. Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37. PLoS ONE [Internet]. 2011 Oct 21 [cited 2020 Jan 21];6(10). Available from: https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC3198734/
6. Mahyar A, Ayazi P, Abbasi M, Dalirani R, Taremiha A, Javadi A, et al. Evaluation of Serum 25-Hydroxy Vitamin D Levels in Children with Acute Bronchiolitis. Arch Pediatr Infect Dis. 2017 Apr 1;5.
7. Beigelman A, Castro M, Schweiger TL, Wilson BS, Zheng J, Yin-DeClue H, et al. Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants. J Pediatr Infect Dis Soc. 2015 Sep;4(3):182–8.
8. Golan-Tripto I, Loewenthal N, Tal A, Dizitzer Y, Baumfeld Y, Goldbart A. Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study. BMC Pediatr. 2021 Apr 30;21(1):211.