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Date Published: 24/09/2024
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DOI: https://doi.org/10.51298/vmj.v542i2.11075
Issue
Vol. 542 No. 2 (2024)
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Các bài báo
How to Cite
Nguyễn, T. H. C., & Phạm, T. A. (2024). PLASMA LEVEL OF LIPOCALIN-2 AND ASSOCIATED FACTORS IN PATIENTS WITH CHRONIC URTICARIA. Vietnam Medical Journal, 542(2). https://doi.org/10.51298/vmj.v542i2.11075

PLASMA LEVEL OF LIPOCALIN-2 AND ASSOCIATED FACTORS IN PATIENTS WITH CHRONIC URTICARIA

Thị Hồng Chuyên Nguyễn, Trường An Phạm

Main Article Content

Abstract

Objective: To investigate the plasma level of LCN2 and associated factors with the clinical manifestations in patients with chronic urticaria (CU). Subject and method: A case series study was conducted on 40 patients with CU at the Ho Chi Minh City Hospital of Dermato-Venereology from October 2019 to July 2020 and 20 healthy people in the control group. Result: Median and interquartile range (IQR) (25–75th percentile) of plasma LCN2 level in CU patients was 104,3 (88,1-160,9) and in the control group was 107 (75,3-162,4) and there was no significant difference (p = 1,000; Mann-Whitney test) between two groups. There was no significant difference between median and IQR (25–75th percentile) plasma LCN2 level in CU patients with BMI ≥ 23kg/m2 (mean 99.3, IQR (88,6-144,2)) and in CU patients with BMI < 23kg/m2 (mean106.6, UQR (85,4-162,7)). The median plasma level of LCN2 in patients with a positive family history of CU  (mean 126,8; IQR 106,6-171,9) was significantly higher than in patients without a family history of CU (mean 95; IQR 77,5-130,3) with p=0.025. Conclusion: The plasma level of LCN2 in the CU patients group had no statistically significant difference from the control group. The median plasma level of LCN2 in patients with a positive family history of CU was significantly higher than in patients without a family history of CU, indicating that this adipokine may be a potential marker of treatment response. Further investigation is needed to provide more insight into the role of LCN2 in the pathogenesis of CU.

Article Details

Keywords

Plasma level of Lipocalin-2, chronic urticaria

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