Article Sidebar

pdf
Date Published: 24/09/2024
Abstract Views: 85
Views pdf: 33
DOI: https://doi.org/10.51298/vmj.v542i2.11075
Issue
Vol. 542 No. 2 (2024)
Section
Các bài báo
How to Cite
Nguyễn, T. H. C., & Phạm, T. A. (2024). PLASMA LEVEL OF LIPOCALIN-2 AND ASSOCIATED FACTORS IN PATIENTS WITH CHRONIC URTICARIA. Vietnam Medical Journal, 542(2). https://doi.org/10.51298/vmj.v542i2.11075

PLASMA LEVEL OF LIPOCALIN-2 AND ASSOCIATED FACTORS IN PATIENTS WITH CHRONIC URTICARIA

Thị Hồng Chuyên Nguyễn, Trường An Phạm

Main Article Content

Abstract

Objective: To investigate the plasma level of LCN2 and associated factors with the clinical manifestations in patients with chronic urticaria (CU). Subject and method: A case series study was conducted on 40 patients with CU at the Ho Chi Minh City Hospital of Dermato-Venereology from October 2019 to July 2020 and 20 healthy people in the control group. Result: Median and interquartile range (IQR) (25–75th percentile) of plasma LCN2 level in CU patients was 104,3 (88,1-160,9) and in the control group was 107 (75,3-162,4) and there was no significant difference (p = 1,000; Mann-Whitney test) between two groups. There was no significant difference between median and IQR (25–75th percentile) plasma LCN2 level in CU patients with BMI ≥ 23kg/m2 (mean 99.3, IQR (88,6-144,2)) and in CU patients with BMI < 23kg/m2 (mean106.6, UQR (85,4-162,7)). The median plasma level of LCN2 in patients with a positive family history of CU  (mean 126,8; IQR 106,6-171,9) was significantly higher than in patients without a family history of CU (mean 95; IQR 77,5-130,3) with p=0.025. Conclusion: The plasma level of LCN2 in the CU patients group had no statistically significant difference from the control group. The median plasma level of LCN2 in patients with a positive family history of CU was significantly higher than in patients without a family history of CU, indicating that this adipokine may be a potential marker of treatment response. Further investigation is needed to provide more insight into the role of LCN2 in the pathogenesis of CU.

Article Details

Keywords

Plasma level of Lipocalin-2, chronic urticaria

References

. Vena G. A., Cassano N. (2017) The link between chronic spontaneous urticaria and metabolic syndrome. Eur Ann Allergy Clin Immunol, 49(5), pp. 208-212.
2. Trinh H. K., Pham L. D., Ban G. Y., et al (2016) Altered systemic adipokines in patients with chronic urticaria. Int Arch Allergy Immunol, 171(2), pp. 102-110.
3. Deng Y., Scherer P. E. (2010) Adipokines as novel biomarkers and regulators of the metabolic syndrome. Annals of the New York academy of sciences, 1212 (2010), pp. E1-E19.
4. Abella V., Scotee M., Conde J., et al (2015), "The potential of lipocalin-2/ NGAL as biomarker for inflammatory and metabolic diseases", Biomarkers, 20(8), pp. 565-571.
5. Chakraborty S., Kaur S., Guha S., et al (2012), "The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer", Biochimica et Biophysica Acta, 1826(1), pp. 129-169.
6. Zuberbier T., Aberer W., Asero R., et al (2018), "The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria", Allergy, 73(7), pp. 1393-1414.
7. Panidis D., Tziomalos K., Koiou E., et al (2010), "The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study", Reproductive Biology and Endocrinology, 8(1), pp. 1-8.
8. Elkhidir A. E., Eltaher H. B., Mohamed A. O. (2017), "Association of lipocalin-2 level, glycemic status and obesity in type 2 diabetes mellitus", BMC Res Notes, 10(1), pp. 2-6.
9. Kamata M., Tada Y., Tatsuda A., et al (2012), "Serum lipocalin-2 levels are increased in patients with psoriasis", Clin Exp Dermatol, 37(3), pp. 296-299.
10. Awede B., Adovoekpe D., Adehan G., et al (2018), "Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA‐IR in subjects of a west‐African population", Physiological Reports, 6(11), p. e13718.