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INVESTIGATING THE ITGB3 GENETIC POLYMORPHISM CHARACTERISTICS IN PATIENTS UNDERGOING CORONARY STENTING INTERVENTION
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Abstract
Objects: Survey of ITGB3 gene polymorphism characteristics and relationship with clopidogrel platelet aggregation response as well as some clinical and paraclinical features in patients undergone coronary artery stenting intervention. Subjects and methods: Cross-sectional descriptive study with 171 patients over 18 years old who were successfully intervented coronary artery stenting and treated with clopidogrel at 175 Military Hospital and 103 Military Hospital from 09/2021 to 12/2022. Results: The majority were men (74.86%) and over 60 years old (59.07%), significant difference compared to women with p<0.05. Smoking also accounts for a high rate (36.26%) and is higher in patients under 60 years old (p<0.05). The main genotype of ITGB3 T1565C was TT with 91.23%, TC genotype accounts for 8.77% and no cases of homozygous recessive CC were recorded. The T and C allele frequencies are 95.61% and 4.39%, respectively. No statistically significant difference was noted when comparing platelet aggregation and clopidogrel resistance by genotype with p>0.05. There is a difference in the amount of damaged coronary artery vessels when comparing TT (1.71±0.77) and TC (2.27±0.88) genotypes with p<0.05. Conclusion: The allele frequencies of ITGB3 T1565C were 95.61% for T and 4.39% for C. No association had been observed between the genotype and the platelet aggregation or clopidogrel resistance. The amount of coronary artery vessel lesions in patients with the TC genotype is higher compared to those with the TT genotype, with p<0.05
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Keywords
ITGB3, genetic polymorphisms, platelet aggregation, clopidogrel, coronary artery disease.
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