ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ CÁC YẾU TỐ NGUY CƠ TỬ VONG Ở NGƯỜI BỆNH COVID-19 NẶNG, ĐIỀU TRỊ TẠI BỆNH VIỆN ĐA KHOA HÀ ĐÔNG (2021-2022)

Abstract

Objective: To find out the clinical and sub-clinical characteristics and risk factors for death in people with severe covid -19. Method: we conducted a retrospective study on 412 people with severe covid -19, treated at Ha Dong General Hospital, period 2021 - 2022. Results: Male/female ratio = 1.07, the disease occured in all age groups, 73.79% were in the > 60 year old group, the proportion of people with underlying diseases was 70.1%, and 66.7% have not been vaccinated against Covid-19. Common clinical manifestations were cough (81.1%), fever (64.6%), chest pain (62.9%), especially circulatory disorders (abnormal heart rate and blood pressure, respectively 59.4% and 44%), consciousness (decreased/comatose 36.2%, restlessness/fatigue 9.7%), anuria/oliguria (32.5%). On sub-clinical: many indicators of disorders, such as hematology, biochemistry, blood coagulation, blood gases and damage on chest X-ray. Multivariable logistic regression analysis, the indicators with independent prognostic value for death were: white blood cells >10G/l (OR=2.6; p=<0.01); Platelets <150x103/mm3 (OR=2.4; p=0.01); Urea >7.5mmo/l (OR=2.7; p=<0.01); Creatinine >120µmol/l (OR=2.6; p=<0.01) and LDH >500ng/ml (OR=2.8; p=<0.01). Conclusion: Clinical manifestations in patients with severe Covid-19 disease are not specific, there is a need for early diagnosis solutions based on screening tests and application of prognostic indicators for appropriate treatment intervention and risk reduction. dead.