OBSTETRIC RISK FACTORS FOR EARLY NEONATAL DEATH IN PREMATURE INFANTS BORN BETWEEN 28 TO 32 WEEKS’ GESTATION

Dương Quỳnh Anh1,, Phạm Thị Thanh Hiền1
1 Hanoi Medical University

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Abstract

Objective: To analyze several obstetric risk factors for early neonatal death in premature babies born between 28 to 32 weeks’ gestation. Subjects and method: This cross-sectional study include singleton live infants born between 28 to 32 weeks of gestation at National hospital of Obstetrics and Gynecology from July 1st 2020 to December 31st 2020. Results: Out of 238 singleton live births in the study, 11 infants died in the first week (4,62%), the majortiy of deaths happened in the first 24 hours (5/11 cases, 45,45%). The leading causes are respiratory failure (55%), infection (18%), intraventricular hemorrhage (18%). 81,82% (9/11 cases) of child had mothers with health problems, increasing the probability of early neonatal death nearly 8 times (OR = 7,96, 95% CI 1,68 – 37,71), particularly blood pressure disorders increase 6,3 times (OR = 6,37, 95% CI 1,84 – 21,98). Preterm babies with intrauterine growth restriction were simutaneously 8,8 times more likely to die in the first week of life (OR = 8,89, 95% CI 2,54 – 31,12). Conclusions: Maternal diseases (especially blood pressure problems) and intrauterine growth restriction were associated with increased risk of early neonatal mortality.

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References

1. Nguyễn Viết Tiến (2012), Sản phụ khoa - Bài giảng cho học viên sau đại học, Nhà xuất bản Y học.
2. Guevvera Y. (2006). World Health Organisation: Neonatal and perinatal mortality: country, regional and global estimates. WHO cebu: sun.
3. Trương Quang Hưng (2018). Khảo sát các yếu tố liên quan đến nguy cơ tử vong sơ sinh sớm của trẻ ở tuổi thai 28 - 32 tuần tại Bệnh viện Hùng Vương. Tạp chí Y học TP Hồ Chí Minh, 22(1), 49.
4. Dương Thanh Long (2012). Đánh giá các yếu tố nguy cơ gây tử vong sơ sinh tại khoa Nhi Bệnh viện ĐKTT An Giang 2010 - 2011. Kỷ yếu Hội nghị Khoa học Bệnh viện An Giang, 203.
5. Trần Diệu Linh, Lê Anh Tuấn, and Phan Thị Thu Nga (2013). Nghiên cứu tình hình bệnh lý và tử vong trẻ sơ sinh non tháng - thấp cân tại Bệnh viện Phụ sản Trung ương năm 2010. Tạp chí Phụ sản, 11(2), 65–69.
6. Aghai Z.H., Goudar S.S., Patel A., et al. (2020). Gender variations in neonatal and early infant mortality in India and Pakistan: a secondary analysis from the Global Network Maternal Newborn Health Registry. Reprod Health, 17(3), 178.
7. Yasmin S., Osrin D., Paul E., et al. (2001). Neonatal mortality of low-birth-weight infants in Bangladesh. Bull World Health Organ, 79(7), 608–614.
8. Roberts D., Brown J., Medley N., et al. (2017). Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev, 3, CD004454.
9. Lee H.C. and Gould J.B. (2006). Survival rates and mode of delivery for vertex preterm neonates according to small- or appropriate-for-gestational-age status. Pediatrics, 118(6), e1836-1844.