HIỆU QUẢ CỦA PIRACETAM TRÊN BỆNH LÝ VIÊM VÕNG MẠC SẮC TỐ: NHÂN MỘT TRƯỜNG HỢP

Abstract

Objective: Evaluate the effectiveness of piracetam in retinitis pigmentosa (RP).  Method: A case report of a clinical trial off label of a patient with retinitis pigmentosa with Piracetam 12g/bottle, 4 courses in 12 months. Result: A male patient, 29 years old, came for examination because of blindness in both eyes. Binocular vision was hand motion, peripheral vision was completely lost. Clinical examination revealed that the anterior segment was normal, the fundus had spongy cell pigments scattered throughout the peripheral retina, spreading to the macular. The patient was diagnosed with retinitis pigmentosa and received a blinded clinical trial with intravenous Piracetam 12g in several courses, each course lasting 5 - 10 consecutive days. After 4 courses, visual acuity of the right eye was counting fingers (CF) 0.7m and the left eye was CF 1.5m, and beside vision in both eyes was widen to 135 degrees of the temporal side. Conclusion: Retinitis pigmentosa is a disease, which seriously threatens vision from a young age. Currently, there is no specific treatment for RP. Ongoing therapies, which are mostly based on genes and cells with extremely high price, are only used for groups of patients with specific gene mutations. Treatment with Piracetam in this off label clinical trial initially improved low vision, but the patient was able to do himself living activities basically daily