MỐI LIÊN QUAN GIỮA ĐIỆN NÃO ĐỒ VÀ LÂM SÀNG Ở BỆNH NHÂN VIÊM NÃO TỰ MIỄN DO KHÁNG THỂ KHÁNG THỤ THỂ N-METHYL- D-ASPARTATE TẠI TRUNG TÂM THẦN KINH BỆNH VIỆN BẠCH MAI

Abstract

Objective: To describe the characteristics of electroencephalography (EEG) and the correlation between EEG findings and clinical manifestations in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis at the Neurology Center, Bach Mai Hospital. Subjects: We selected 50 who were diagnosed with encephalitis at Bach Mai Hospital from January 1^st 2020 to October 31^st, 2023. Methods: Cross-sectional descriptive study. Results: Among the 50 patients with anti-NMDAR autoimmune encephalitis, 74% exhibited abnormalities on EEG. The most commonly observed EEG abnormalities were delta brush waves (44%) and diffuse slow waves (38%). Epileptiform discharges were associated with clinical seizures with p<0,05. All patients with epileptiform discharges experienced clinical seizures. However, 74,1% of cases with clinical seizures did not show epileptiform discharges. Delta brush EEG abnormalities were correlated with movement disorder symptoms with p<0,05. There were no statistically significant differences between EEG characteristics and psychiatric disorders, consciousness impairment, or autonomic nervous system dysfunction. Conclusion: This study indicates that the majority of patients with anti-NMDAR autoimmune encephalitis show EEG abnormalities, with diffuse slow waves and delta brush being the most common. Epileptiform discharges are associated with clinical seizures, while delta brush waves are related to movement disorder symptoms