MỐI TƯƠNG QUAN GIỮA NỒNG ĐỘ CỦA MỘT SỐ CYTOKINE, KHÁNG THỂ VÀ MỨC ĐỘ HOẠT ĐỘNG CỦA VIÊM KHỚP DẠNG THẤP

Abstract

Background: Serum cytokine levels and their relationship to the disease activity of rheumatoid arthritis  have become the subject of numerous studies worldwide. However, data on this issue remain scarce in Vietnam. Objectives: The study aim to evaluate the correlation between the concentrations of certain cytokines and the VAS and DAS28 scale in patients with rheumatoid arthritis. Materials and methods: A cross-sectional descriptive study was conducted on 62 patients diagnosed and treated for rheumatoid arthritis at the Department of Rheumatology, Cho Ray Hospital, from April 2023 to January 2024. Results: The research population had a mean age of 56.7 ± 9.8 years, with a male-to-female ratio of approximately 1:4. The results indicated that the levels of the surveyed cytokines and antibodies were elevated. The average VAS, DAS28, and concentration of CRP were 36.71 ± 16.12, 7.17 ± 0.89, and 63.28 ± 60.48 mg/L, respectively, reflecting moderate to high disease activity in rheumatoid arthritis. Spearman correlation analysis showed that IL-1α, IL-4, VEGF, IFN-γ, TNF-α, and RF had positive correlations with the DAS28 score (p < 0.05). Among these, IL-1α, IL-4, and IFN-γ exhibited moderate correlations (r: 0.378; 0.309, and 0.308), while VEGF, TNF-α, and RF showed weak correlations (r: 0.243; 0.268, and 0.236). Regarding the VAS score, only IL-1α, IL-4, and IFN-γ demonstrated moderate positive correlations (r: 0.331; 0.314, and 0.300; p < 0.01). Conclusion: The key findings of this study suggest that, in the context of moderate to high disease activity, several cytokine markers, including IL-1α, IL-4, and IFN-γ, have significant positive correlations with both the VAS and DAS28. Additionally, VEGF, TNF-α, and RF also exhibit weak correlations with the DAS28.