ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA NGƯỜI BỆNH U LYMPHO KHÔNG HODGKIN TẾ BÀO B LỚN LAN TỎA BIỂU HIỆN Ở VÚ

Abstract

Objective: To describe the clinical and subclinical characteristics of patients with diffuse large B-cell lymphoma of breast (DLBCL). Subjects and methods: A descriptive study of 33 patients with breast DLBCL were treated at National Cancer  Hospital from January 2019 to June 2024. Results: The average age of patients was 52 that commonly ranged from 41 to 60 (51,5%). 100% of the patients were female. The time of disease detection often was less than 3 months. The most common symptom was palpable painless breast mass (78,8%), additionally 9,1% had palpable axillary lymph nodes and 12,2% had pain or swelling breast; 24,2% had B symptoms. 48,5% had tumor in the right breast, 30,3% in the left breast and 21,2% in both breasts, with 21,2% bulky tumors. 27,2% of patients were anemia 100% of patients had no envidence of bone marrow invasion. B2-M increasing was found in 45,5%, and 15,2% had LDH increasing. Breast ultrasound: 90,9% showed hypoechogenicity, 60,6% had single mass, 97% had irregular borders. Mammography: 94,7% had increased breast density. 100% were diagnosed by hispathology (81,8% breast biopsy  and 18,2% postoperative specimen): 90,9% were non-germinal center type and 69,7% had a high Ki67 index (>70%). NCCN-IPI was in the majority low and intermediate - low risk group, respectively 39,4% and 54,5%. Conclusion: Breast DLBCL commonly occurs in females at the age group of 41-60, was diagnosed within 3 months, with the most common symptom are palpaple painless mass in many areas of breasts. Most cases show hypoechogennocity in ultrasound and increased density on mammography. Hispathology is majority with non-germinal center type and a high Ki67 index. Most of patients are in the low and intermediate-low risk groups according to the NCCN-IPI.