ĐÁNH GIÁ TÌNH TRẠNG KHÁNG NÚT MẠCH HÓA CHẤT Ở BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAN TẠI BỆNH VIỆN BẠCH MAI

Abstract

Objective: Describe the clinical and subclinical characteristics of patients with hepatocellular carcinoma (HCC) refractory to chemoembolization (TACE) at Bach Mai Hospital and evaluate some related factors. Methods: During the period from January 2022 to December 2023, 44 patients diagnosed with unresectable HCC were treated with TACE and were followed up after treatment. TACE refractoriness criteria are based on the Japanese Society of Gastroenterology (JSH) criteria including intrahepatic lesions, tumor markers, vascular invasion, and extrahepatic spread. Results: 17 patients were identified as TACE refractoriness, increased alpha-fetoprotein (AFP) (58.8%) and new intrahepatic lesions (52.9%) were the most common TACE refractoriness characteristics. Median age was 59 years, 88.2% of patients were male. 70.6% of patients had a history of hepatitis B. 94.1% of patients had 1-2 tumors and 58.8% had the largest tumor over 3cm. On multivariate logistic regression analysis, age, history of hepatitis B, tumor number, size, and AFP were not associated with the risk of TACE refractoriness. Conclusion: The rate of TACE refractoriness in HCC patients at Bach Mai hospital was 38.6%. Further evaluation of associated factors and prognostic treatment is needed in future studies