MỐI LIÊN QUAN GIỮA MAU (+), UACR (+) VÀ ĐỘ LỌC CẦU THẬN ƯỚC TÍNH Ở BỆNH NHÂN ĐỘT QUỴ

Abstract

Background: Stroke is a common cerebrovascular disease that can cause many dangerous complications, including kidney damage. Microalbuminuria (MAU) and urine albumin-to-creatinine ratio (UACR) are early signs of kidney damage. Objective: To investigate the association between microalbuminuria (MAU) and urine albumin-to-creatinine ratio (UACR) with estimated glomerular filtration rate (eGFR) in stroke patients. Methods: A cross-sectional study was conducted on 202 stroke patients at Thong Nhat Hospital from August to December 2023. Urinary albumin and creatinine were measured by immunoturbidimetry, and serum creatinine was measured by kinetic Jaffe method. eGFR was calculated using the CKD-EPI 2021 equation. MAU(+) was defined as urinary albumin >20 mg/L and UACR(+) was defined as >3 mg/mmol. Results: Of the 202 patients, 63.4% had MAU (+) and 58% had UACR (+). Patients with MAU (+) had higher mean serum creatinine and lower eGFR than those with MAU (-). The proportion of MAU (+) increased as eGFR decreased. The proportion of UACR (+) also increased as eGFR decreased. When eGFR was <30 ml/min/1.73m², the proportion of UACR >30 mg/mmol increased significantly and the proportion of UACR <3 mg/mmol decreased significantly (p=0.003). Conclusion: MAU (+) and UACR (+) are associated with decreased eGFR in stroke patients. UACR is better than MAU in assessing the degree of renal impairment and prognosis of stroke patients.