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Date Published: 17/10/2024
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DOI: https://doi.org/10.51298/vmj.v543i2.11434
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Vol. 543 No. 2 (2024)
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Các bài báo
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Nguyễn, H. N., Nguyễn, K. L., Trần, B. K., Mai, H. T., & Ngô, V. Đàn. (2024). CHARACTERISTICS OF QUANTITATIVE PARAMETERS AND HETEROGENEITY ON 18F-FDG PET/CT IN SURGICALLY NON-SMALL CELL LUNG CANCER PATIENTS. Vietnam Medical Journal, 543(2). https://doi.org/10.51298/vmj.v543i2.11434

CHARACTERISTICS OF QUANTITATIVE PARAMETERS AND HETEROGENEITY ON 18F-FDG PET/CT IN SURGICALLY NON-SMALL CELL LUNG CANCER PATIENTS

Hải Nguyễn Nguyễn, Kim Lưu Nguyễn, Bá Khoa Trần, Huy Thông Mai, Văn Đàn Ngô

Main Article Content

Abstract

Objective: To investigate the characteristics of quantitative parameters and heterogeneity of 18F-FDG PET/CT in patients with non-small cell lung cancer (NSCLC) at a stage where surgery is indicated. Subjects and methods: This retrospective cross-sectional study was conducted on 55 patients with NSCLC who underwent PET/CT imaging before specific treatment at the Department of Nuclear Medicine, 103 Military Hospital, from January 2017 to January 2024. Data were analyzed using SPSS 26.0 software, employing T-tests and Mann-Whitney U tests, kruskal-wallis test and ANOVA test to compare PET/CT parameters. All analyses were two-tailed, with statistical significance set at p<0.05. Results: The majority of patients were male, with a male-to-female ratio of 2.67:1, and the mean age was 59.0 ± 11.6 years. The median values for MTV, MTV 41%, TLG, and TLG 41% were 11.8, 10.2, 95.9, and 73.0, respectively. The mean values for CoV b and CoV 41% were 27.87 ± 5.34 and 23.81 ± 3.05, respectively. Statistically significant differences were found between the quantitative parameters and both the T stage and disease stage. Patients with regional lymph node metastasis had higher MTV, TLG, and CoV parameters than those without regional lymph node metastasis. Conclusion: The volumetric parameters and heterogeneity parameters on 18F-FDG PET/CT images in surgically indicated NSCLC patients are significantly valuable for image analysis and provide useful information for treatment planning.

Article Details

Keywords

Heterogeneity, quantitative parameters, PET/CT, non-small cell lung cancer

References

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